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  6. BD Horizon™ CD25 Mouse, anti-Human, RY586, Clone: 2A3, BD Horizon™

BD Horizon™ CD25 Mouse, anti-Human, RY586, Clone: 2A3, BD Horizon™

Catalog No. p-7225549 Shop All BD Biosciences Products
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100 Tests
25 Tests
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BDB568125 25 Tests
BDB568124 100 Tests
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Catalog No. BDB568125 Supplier BD Horizon™ Supplier No. 568125
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Description

Mouse Monoclonal Antibody

The 2A3 monoclonal antibody specifically binds to human CD25, the low-affinity alpha subunit of the Interleukin-2 Receptor (IL- 2Rα). CD25 associates with CD122 (IL-2Rβ chain) and CD132 (common γ chain or γc) to form the high-affinity signal-transducing IL-2R complex. CD25 is expressed by subsets of thymocytes and peripheral blood lymphocytes including CD4+CD25+ regulatory T cells and memory T cells. CD25 antigen density increases on activated T cells including phytohemagglutinin (PHA)-, concanavalin A (Con A)-, and CD3-activated T lymphocytes. High levels of CD25 can be expressed by T lymphocytes from mixed lymphocyte cultures and by human T-lymphocyte leukemia virus (HTLV)-infected T-lymphocyte leukemia lines, for example, HUT-102. CD25 can also be expressed by activated B cells and macrophages. Recombinant IL-2 blocks the binding of the 2A3 antibody to PHA-activated T lymphocytes.

TRUSTED_SUSTAINABILITY

Specifications

Antigen CD25
Applications Flow Cytometry
Clone 2A3
Conjugate RY586
Host Species Mouse
Quantity 25 Tests
Regulatory Status RUO
Primary or Secondary Primary
Target Species Human
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