Invitrogen™ CD263 (TRAIL-R3) Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA519932

Catalog No. PIPA519932

Description

In Western blot applications, this antibody detects a band at ~65kDa. A suggested positive control is Hela cell lysate. PA5-19932 can be used with blocking peptide PEP-0057.

TRAIL-R3 (CD263) is a member of the TNF-receptor superfamily. This receptor contains an extracellular TRAIL-binding domain and a transmembrane domain, but no cytoplasmic death domain. This receptor is not capable of inducing apoptosis, and is thought to function as an antagonistic receptor that protects cells from TRAIL-induced apoptosis. This gene was found to be a p53-regulated DNA damage-inducible gene. The expression of this gene was detected in many normal tissues but not in most cancer cell lines, which may explain the specific sensitivity of cancer cells to the apoptosis-inducing activity of TRAIL.

Specifications

• Antigen: CD263 (TRAIL-R3)
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: TNFRSF10C
• Gene Alias: Antagonist decoy receptor for TRAIL/Apo-2L; CD263; cytotoxic TRAIL receptor-3; DCR1; DCR1-TNFR; Decoy receptor 1; decoy TRAIL receptor without death domain; LIT; lymphocyte inhibitor of TRAIL; MGC149501; MGC149502; TNF receptor superfamily member 10c; TNF-related apoptosis-inducing ligand receptor 3; TNFRSF10C; TRAIL receptor 3; TRAIL receptor without an intracellular domain; TRAILR3; TRAIL-R3; TRID; Tumor necrosis factor receptor superfamily member 10C; tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain; UNQ321/PRO366
• Host Species: Rabbit
• Purification Method: Ion-exchange Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 8794
• Content And Storage: Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
• Form: Liquid

• Applications: Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 0.02% sodium azide
• Gene Accession No.: O14798
• Gene Symbols: TNFRSF10C
• Immunogen: A peptide corresponding to amino acids in a extracellular domain of human DcR1 precursor.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG