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CD267 (TACI) Monoclonal Antibody (ebio8F10-3), APC, eBioscience™, Invitrogen™
Rat Monoclonal Antibody
$145.00 - $260.00
Specifications
Antigen | CD267 (TACI) |
---|---|
Clone | ebio8F10-3 |
Concentration | 0.2 mg/mL |
Applications | Flow Cytometry |
Classification | Monoclonal |
Description
Description: The monoclonal antibody eBio8F10.3 recognizes TACI (Transmembrane Activator and Calcium-modulator and CAML Interactor) also known as CD267. TACI is a type III membrane protein belonging to the TNF receptor superfamily. The ligand for TACI has been shown to be BAFF (BLyS) and APRIL. TACI is expressed on the surface of a subset of maturing splenic B cells of the transitional type termed T2. Genetic studies have shown a role for TACI in both stimulation and inhibition of B cell proliferation. This actual role for TACI in the mouse has still not been determined. Recently human TACI has been shown to have repressive activities which inhibit BAFF-R function. Applications Reported: This ebio8F10-3 antibody has been reported for use in flow cytometric analysis. Applications Tested: This ebio8F10-3 antibody has been tested by flow cytometric analysis of mouse splenocytes. This can be used at less than or equal to 0.25 μg per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. Excitation: 633-647 nm; Emission: 660 nm; Laser: Red Laser. Filtration: 0.2 μm post-manufacturing filtered.
Members in the TNF superfamily regulate immune responses and induce apoptosis. Two novel members in the TNF family were recently identified and designated BAFF/BLyS/TALL-1/THANK/zTNF4 and April/TALL-2, respectively. BAFF was characterized as a B cell activator since it induced B cell proliferation and immunoglobulin secretion. April regulates immunological and non-immunological cell growth. Three receptors, BCMA, TACI, and BAFF-R, for BAFF and April were recently identified. TACI, like BCMA, binds BAFF and April. TACI and its ligands regulate humoral immune responses, activate NF-kappa-B and c-jun N-terminal kinase, and are involved in B cell associated autoimmune diseases.Specifications
CD267 (TACI) | |
0.2 mg/mL | |
Monoclonal | |
Liquid | |
RUO | |
PBS with 0.09% sodium azide; pH 7.2 | |
1200009E08Rik; CD267; CVID; CVID2; IGAD2; NEWGENE_1595998; RYZN; TACI; TNF receptor superfamily member 13B; Tnfrsf13b; TNFRSF14B; transmembrane activator and calcium-modulating and cyclophilin ligand interactor; transmembrane activator and CAML interactor; tumor necrosis factor receptor 13B; tumor necrosis factor receptor superfamily member 13B; tumor necrosis factor receptor superfamily, member 13B | |
TNFRSF13B | |
Primary | |
4°C, store in dark, DO NOT FREEZE! | |
TNFRSF13B |
ebio8F10-3 | |
Flow Cytometry | |
APC | |
Rat | |
Mouse | |
Q9ET35 | |
57916 | |
IgG2a κ | |
Affinity chromatography | |
Antibody |
For Research Use Only.
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