Invitrogen™ CD274 (PD-L1, B7-H1) Monoclonal Antibody (MIH5), NovaFluor™ Yellow 700, eBioscience™, Invitrogen™

Rat Monoclonal Antibody

Supplier:  Invitrogen™ M036T03Y06A

Catalog No. M036T03Y06A

Description

Programmed death receptor ligand 1 (PD-L1, also called B7-H1) is a recently described B7 family member. To date, one specific receptor has been identified that can be ligated by PD-L1. This receptor, programmed death receptor 1 (PD-1), has been shown to negatively regulate T-cell receptor (TCR) signaling. Upon ligating its receptor, PD-L1 has been reported to decrease TCR-mediated proliferation and cytokine production. PD-L1 expression was found to be abundant on many murine and human cancers and could be further up-regulated upon IFN-gamma stimulation. Thus, PD-L1 might play an important role in tumor immune evasion.

Specifications

• Antigen: CD274 (PD-L1, B7-H1)
• Classification: Monoclonal
• Concentration: 0.1 mg/mL
• Formulation: PBS with 0.09% sodium azide; pH 7.2
• Gene Accession No.: Q9EP73
• Gene Symbols: Cd274
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 60533
• Content And Storage: 4°C, store in dark, DO NOT FREEZE!
• Form: Liquid
• Isotype: IgG2a λ

• Applications: Flow Cytometry
• Clone: MIH5
• Conjugate: NovaFluor Yellow 700
• Gene: Cd274
• Gene Alias: A530045L16Rik; B7 homolog 1; B7-H; B7h1; B7-H1; Cd274; CD274 antigen; CD274 molecule; PDCD1 ligand 1; Pdcd1l1; Pdcd1lg1; Pdl1; PD-L1; pdl-1; Programmed cell death 1 ligand 1; programmed death ligand 1; RGD1566211; sCD274; soluble CD274; soluble PD L1; sPD L1
• Host Species: Rat
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Mouse
• Product Type: Antibody
• Format: Liquid