CD279 Mouse anti-Human, PE, Clone: MIH4, BD

Catalog No.	Quantity
BDB560908	25 Tests
BDB557946	100 Tests

Catalog No. BDB560908 Supplier BD Biosciences Supplier No. 560908

Description

Mouse Monoclonal Antibody

The MIH4 monoclonal antibody specifically binds to the program death 1 (PD-1) receptor CD279, a member of the Ig superfamily. CD279 is an immunoregulatory receptor expressed on activated T cells, B cells and myeloid cells. Mice deficient in CD279 show a breakdown of peripheral tolerance and manifest multiple autoimmune symptoms. It contains an immunoreceptor tyrosine-based inhibitory motif (ITIM) in the cytoplasmic region. PD-L1 and PD-L2 are ligands of CD279 and are members of the B7 gene family. Interaction of CD279:PD-Ligands results in inhibition of T cell proliferation and cytokine secretion. Reports suggest that the B7/CTLA-4 pathway functions primarily to attenuate, limit, and/or terminate naοve T-cell activation in secondary lymphoid organs. The PD-ligand:CD279 pathway, on the other hand, may primarily attenuate, limit, and/or terminate T-, B-, and myeloid cell activation/effector function at sites of inflammation in the periphery.

Specifications

• Antigen: CD279
• Applications: Flow Cytometry
• Classification: Monoclonal
• Clone: MIH4
• Conjugate: PE
• Description: PD-1; hPD-1; PD1; PDCD1; Programmed cell death 1; SLEB2
• Formulation: Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
• Host Species: Mouse
• Immunogen: Human PD-1 Transfected Cell Line
• Purification Method: Affinity Purified
• Quantity: 25 Tests
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Target Species: Human
• Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
• Isotype: IgG1 κ

For Research Use Only.