CD279 Mouse anti-Human, PE, Clone: MIH4, BD

Mouse Monoclonal Antibody

Catalog Number	Mfr. No.	Quantity
BDB560908	BD Biosciences 560908	25 Tests
BDB557946	BD Biosciences 557946	100 Tests

Description

The MIH4 monoclonal antibody specifically binds to the program death 1 (PD-1) receptor CD279, a member of the Ig superfamily. CD279 is an immunoregulatory receptor expressed on activated T cells, B cells and myeloid cells. Mice deficient in CD279 show a breakdown of peripheral tolerance and manifest multiple autoimmune symptoms. It contains an immunoreceptor tyrosine-based inhibitory motif (ITIM) in the cytoplasmic region. PD-L1 and PD-L2 are ligands of CD279 and are members of the B7 gene family. Interaction of CD279:PD-Ligands results in inhibition of T cell proliferation and cytokine secretion. Reports suggest that the B7/CTLA-4 pathway functions primarily to attenuate, limit, and/or terminate naοve T-cell activation in secondary lymphoid organs. The PD-ligand:CD279 pathway, on the other hand, may primarily attenuate, limit, and/or terminate T-, B-, and myeloid cell activation/effector function at sites of inflammation in the periphery.

Specifications

• Antigen: CD279
• Applications: Flow Cytometry
• Conjugate: PE
• Regulatory Status: RUO
• Formulation: Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
• Isotype: IgG1 κ
• Purification Method: Affinity Purified
• Description: PD-1; hPD-1; PD1; PDCD1; Programmed cell death 1; SLEB2

• Clone: MIH4
• Classification: Monoclonal
• Host Species: Mouse
• Target Species: Human
• Immunogen: Human PD-1 Transfected Cell Line
• Primary or Secondary: Primary
• Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.

For Research Use Only.