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  6. BD Horizon™ CD279 Mouse, anti-Human, RY586, Clone: EH12.1, BD Horizon™

BD Horizon™ CD279 Mouse, anti-Human, RY586, Clone: EH12.1, BD Horizon™

Catalog No. p-7225543 Shop All BD Biosciences Products
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25 Tests
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BDB568119 25 Tests
BDB568118 100 Tests
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Catalog No. BDB568119 Supplier BD Horizon™ Supplier No. 568119
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Description

Mouse Monoclonal Antibody

The EH12.1 monoclonal antibody specifically binds to CD279 which is also known as Programmed cell death 1 (PD1). CD279 is an immunoregulatory receptor  expressed on activated T cells, B cells, and myeloid cells. It contains an immunoreceptor tyrosine-based inhibitory motif (ITIM) in the cytoplasmic region. Mice deficient in CD279 show a breakdown of peripheral tolerance and manifest multiple autoimmune symptoms. PD-L1 and PD-L2 are ligands of CD279 and members of the B7 gene family. CD279:PD-Ligands interaction inhibits T cell proliferation and cytokine secretion. Reports suggest that the B7/CTLA-4 pathway primarily attenuates, limits, and/or terminates naïve T-cell activation in secondary lymphoid organs. The PD-ligand:CD279 pathway, on the other hand, may primarily attenuate, limit, and/or terminate T-, B-, and myeloid cell activation/effector function at sites of inflammation in the periphery.

TRUSTED_SUSTAINABILITY

Specifications

Antigen CD279
Applications Flow Cytometry
Clone EH12.1
Conjugate RY586
Host Species Mouse
Quantity 25 Tests
Regulatory Status RUO
Primary or Secondary Primary
Target Species Human
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