Invitrogen™ CD279 (PD-1) Monoclonal Antibody (EH12.2H7), PE

Catalog No.	Quantity
PIMA528583	100 Tests

Catalog No. PIMA528583 Supplier Invitrogen™ Supplier No. MA528583

Description

Mouse Monoclonal Antibody

This antibody recognizes an extracellular epitope of CD279 / PD-1 (programmed cell death 1), a 55 kDa type I transmembrane protein expressed above all during T cell development, on activated T cells, activated B cells, and activated monocytes. Recommended dilution is for 100 μL of whole blood or 1x10^6 cells in suspension.

Cell-mediated immune responses are initiated by T lymphocytes that are themselves stimulated by cognate peptides bound to MHC molecules on antig en-presenting cells (APC). T-cell activation is generally self-limited as activated T cells express receptors such as PD-1 (also known as PDCD-1) that mediate inhibitory signals from the APC. PD-1 can bind two different but related ligands, PDL-1 and PDL-2. Upon binding to either of these ligands, signals generated by PD-1 inhibit the activation of the immune response in the absence of 'danger signals' such as LPS or other molecules associated with bacteria or other pathogens. Evidence for this is seen in PD1-null mice who exhibit hyperactivated immune systems and autoimmune diseases. Despite its predicted molecular weight, PD-1 often migrates at higher molecular weight in SDS-PAGE.

Specifications

• Antigen: CD279 (PD-1)
• Applications: Flow Cytometry
• Classification: Monoclonal
• Clone: EH12.2H7
• Concentration: 0.04 mg/mL
• Conjugate: PE
• Formulation: PBS with 0.2% BSA and 15mM sodium azide; pH 7.4
• Gene: Pdcd1
• Gene Accession No.: Q15116
• Gene Alias: CD279; EGK_05005; hPD1; hPD-1; hPD-l; hSLE1; Ly101; mPD-1; PD1; PD-1; Pdc1; Pdcd1; programmed cell death 1; programmed cell death 1 protein; programmed cell death protein 1; programmed cell death protein 1-like; programmed death 1; Protein PD1; protein PD-1; sCD279; SLEB2; soluble CD279; systemic lupus erythematosus susceptibility 2
• Gene Symbols: Pdcd1
• Host Species: Mouse
• Immunogen: recombinant human CD279.
• Purification Method: Size-exclusion chromatography
• Quantity: 100 Tests
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 100135775, 100400173, 101044440, 102123659, 5133, 748796
• Target Species: Chimpanzee, Cynomolgus Monkey, Human, Monkey, Rhesus Macaque
• Content And Storage: 4°C, store in dark, DO NOT FREEZE!
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG1 κ

Safety and Handling

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