Invitrogen™ CD300b Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5120746

Catalog No. PIPA5120746

Description

Positive test controls include: Mouse lung, Rat lung. Immunogen sequence: MWLPPALLLL SLSGCFSIQG PESVRAPEQG SLTVQCHYKQ GWETYIKWWC RGVRWDTCKI LIETRGSEQG EKSDRVSIKD NQKDRTFTVT MEGLRRDDAD VYWCGIERRG PDLGTQVKVI VDPEGAASTT ASSPTNSNMA VFIGSHKRNH YMLLVFVKVP ILLILVTAIL WLKGSQRVPE EPGEQPIYMN FSEPLTKDMA T.

CD300 molecule-like family member b (CD300LB), also known as CLM-7, is a gene located on chromosome 17q25.1, encoding an immunoreceptor that belongs to the CD300 family of molecules. CD300LB is primarily expressed on the surface of myeloid cells, including dendritic cells and macrophages, where it plays an essential role in modulating immune responses. The receptor is involved in the regulation of cell activation and inflammatory responses through its interactions with phosphatidylserine and other lipid ligands, which can lead to either activation or inhibition of immune cell functions. CD300LB influences processes like antigen presentation, phagocytosis, and cytokine production, thereby impacting innate immune responses and the maintenance of immune homeostasis. Its expression and activity are of particular interest in contexts like autoimmunity, infection, and cancer, where it may contribute to disease progression and serve as a potential therapeutic target in modulating immune functions.

Specifications

• Antigen: CD300b
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: CD300LB
• Gene Alias: CD300 antigen like family member B; CD300 antigen-like family member B; CD300 molecule like family member b; CD300 molecule-like family member b; CD300b; CD300LB; CLM7; CLM-7; CMRF35A2; CMRF35-A2; CMRF35-like molecule 7; CMRF-35-like molecule-7; Gm253; Immune receptor expressed on myeloid cells 3; IREM3; IREM-3; Leukocyte mono-Ig-like receptor 5; LMIR5; TREM5; TREM-5; triggering receptor expressed on myeloid cells 5; UNQ2530/PRO6029
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 124599, 217304, 501738
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 1.95 mg/mL
• Formulation: PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
• Gene Accession No.: A8K4G0, Q3U497
• Gene Symbols: CD300LB
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-201 of human CD300LB (NP_777552.3).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG