Invitrogen™ CD300e Monoclonal Antibody (UP-H2)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA544078

Catalog No. PIMA544078

Description

This antibody recognizes an extracellular epitope on CD300e / IREM-2, a 32 kDa glycoprotein expressed by mature monocytes and peripheral blood myeloid dendritic cells. Functional application: Stimulation.

CD300e is a member of the glycoprotein family of cell surface proteins expressed on myeloid cells. CD300e interacts with the TYRO protein tyrosine kinase-binding protein and is thought to be involved as an activating receptor. CD300e is expressed on mature myeloid dendritic cells and monocytes, and is down regulated on immature dendritic cells. Further, CD300e interacts with DAP-12, which mediates activating signals. The alloreactive response of naïve T cells has been reported to become enhanced by the activation of CD300e. Diseases associated with CD300e dysfunction include tungiasis and lice infestation.

Specifications

• Antigen: CD300e
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with no preservative; pH 7.4
• Gene Accession No.: Q496F6
• Gene Symbols: CD300E
• Immunogen: CD300e-HA-transfected cells.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1 κ

• Applications: Flow Cytometry, Functional Assay, Immunoprecipitation, Western Blot
• Clone: UP-H2
• Conjugate: Unconjugated
• Gene: CD300E
• Gene Alias: BC034097; CD300 antigen like family member E; CD300 antigen-like family member E; CD300e; CD300e antigen; CD300e molecule; Cd300le; CLM2; CLM-2; CMRF35A5; CMRF35-A5; CMRF35-like molecule 2; CMRF-35-like molecule-1; Immune receptor expressed on myeloid cells 2; IREM2; IREM-2; PIgR2; PIgR-2; poly-Ig receptor 2; polymeric immunoglobulin receptor 2; TREM5
• Host Species: Mouse
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 342510
• Content And Storage: 4°C, do not freeze
• Form: Liquid