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Invitrogen™ CD31 Monoclonal Antibody (HEC7)
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Catalog No. ENMA3100
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200 μg
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Catalog No. Quantity
ENMA3100 200 μg
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Catalog No. ENMA3100 Supplier Invitrogen™ Supplier No. MA3100
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Description

Mouse Monoclonal Antibody

MA3100 targets CD31 in ICC/IF and ACS applications and shows reactivity with Human and Bovine samples. The MA3100 immunogen is human PECAM-1. MA3100 detects CD31 which has a predicted molecular weight of approximately 80 kDa. This product has been tested for endotoxins by limulus amoebocyte lysate (LAL) assay and contains an endotoxin concentration of less than or equal to 10 endotoxin units per milligram (EU/mg).

CD31 (platelet endothelial cell adhesion molecule-1, PECAM-1) is an inhibitory coreceptor involved in regulation of T cell and B cell signaling by a dual immunoreceptor tyrosine-based inhibitory motif (ITIM) that upon associated kinases-mediated phosphorylation provide docking sites for protein-tyrosine phosphatases. CD31 is expressed ubiquitously within the vascular compartment and is located mainly at junctions between adjacent cells. N-terminal Ig-like domain of CD31 is responsible for its homophilic binding, which plays an important role in cell-cell interactions. CD31 is a multifunctional molecule with diverse roles in modulation of integrin-mediated cell adhesion, transendothelial migration, angiogenesis, apoptosis, negative regulation of immunoreceptor signaling, autoimmunity, macrophage phagocytosis, IgE-mediated anaphylaxis and thrombosis. It is one of key regulatory molecules in vascular system.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CD31
Applications Flow Cytometry, Western Blot, Immunocytochemistry
Classification Monoclonal
Clone HEC7
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with no preservative
Gene Pecam1
Gene Accession No. P16284, P51866
Gene Alias C85791; CD31; CD31 antigen; CD31, PECAM-1; CD31/EndoCAM; endoCAM; GPIIA'; I79_008304; PECA1; Pecam; PECAM1; Pecam-1; platelet and endothelial cell adhesion molecule 1; platelet endothelial cell adhesion molecule; platelet endothelial cell adhesion molecule-1; platelet/endothelial cell adhesion molecule (CD31 antigen); platelet/endothelial cell adhesion molecule 1; type I transmembrane endothelial adhesion molecule
Gene Symbols Pecam1
Host Species Mouse
Immunogen Human PECAM-1.
Purification Method Protein G
Quantity 200 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 282303, 5175
Target Species Bovine, Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG2a
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