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  6. Invitrogen™ CD314 (NKG2D) Monoclonal Antibody (1D11), Functional Grade, eBioscience™, Invitrogen™ 

Invitrogen™ CD314 (NKG2D) Monoclonal Antibody (1D11), Functional Grade, eBioscience™, Invitrogen™

Catalog No. p-7218656
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16-587-838 5 mg
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Catalog No. 16-587-838 Supplier Invitrogen™ Supplier No. 16587838
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Description

Mouse Monoclonal Antibody

The 1D11 MAb reacts with the human NKG2D, a 42 kDa lectin-like molecule expressed by NK cells, gamma delta T cells, CD8+ T cells, and some CD4+ T cells. Human NKG2D forms complexes with DAP10, a membrane adaptor protein, and has the ability to costimulate multiple NK activation receptors. The counter-receptor for human NKG2D has been identified as MICA/MICB expressed on epithelial tumors from lung, breast, kidney, ovary, prostate and colon carcinoma. 5C6 and 1D11 block binding of soluble MICA to gamma delta TCR T cell clones and inhibit lysis by these cells. 5C6 and 1D11 induced NKG2D function of redirected lysis of FcReceptor bearing P815 cells.

Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. NK cells can regulate specific humoral and cell-mediated immunity, and preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. The NK gene encodes a member of the NKG2 family, and the encoded transmembrane protein is characterized by a type II membrane orientation (extracellular C terminus) and the presence of a C-type lectin domain. The NKG2 gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed in NK cells.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CD314 (NKG2D)
Applications Flow Cytometry, Functional Assay, Neutralization
Classification Monoclonal
Clone 1D11
Concentration 1 mg/mL
Conjugate Functional Grade
Formulation PBS with no preservative; pH 7.2
Gene Klrk1
Gene Accession No. P26718
Gene Alias CD314; D12S2489E; D6H12S2489E; killer cell lectin like receptor K1; Killer cell lectin-like receptor subfamily K member 1; killer cell lectin-like receptor subfamily K, member 1; KLR; Klrk1; natural killer cell group 2D; natural killer cell receptor; NK cell receptor D; NK lectin-like receptor; Nkg2d; NKG2-D; NKG2-D type II integral membrane protein; NKG2-D-activating NK receptor; NKLLR; Nkrp2; NKR-P2; NKR-P2, ortholog of human NKG2D
Gene Symbols Klrk1
Host Species Mouse
Purification Method Affinity chromatography
Quantity 5 mg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 22914
Target Species Human
Content And Storage 4°C
Product Type Antibody
Form Liquid
Isotype IgG1 κ
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Safety and Handling

WARNING: Cancer and Reproductive Harm - www.P65Warnings.ca.gov
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