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  6. Invitrogen™ CD314 (NKG2D) Monoclonal Antibody (CX5), Functional Grade, eBioscience™, Invitrogen™ 

Invitrogen™ CD314 (NKG2D) Monoclonal Antibody (CX5), Functional Grade, eBioscience™, Invitrogen™

Catalog No. 16588238
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Catalog No. 16-588-238 Supplier Invitrogen™ Supplier No. 16588238
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Description

Rat Monoclonal Antibody

The CX5 MAb reacts with the mouse NKG2D, a lectin-like molecule expressed on both human and mouse NK cells. Mouse NKG2D binds to retinoic acid-inducible RAE-1alpha, -beta, -gamma, -delta, -ε and the minor histocompatibility molecule H60 and has the ability to costimulate multiple NK activation receptors, through the DAP12/DAP10 adaptor molecules. NKG2D is expressed by all spleen and liver NK cells, NK1.1^+ thymocytes, in vitro activated LAK cells, and a subset of splenic NKT cells.

Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. NK cells can regulate specific humoral and cell-mediated immunity, and preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. The NK gene encodes a member of the NKG2 family, and the encoded transmembrane protein is characterized by a type II membrane orientation (extracellular C terminus) and the presence of a C-type lectin domain. The NKG2 gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed in NK cells.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CD314 (NKG2D)
Applications Flow Cytometry, Functional Assay, Neutralization
Classification Monoclonal
Clone CX5
Concentration 1 mg/mL
Conjugate Functional Grade
Formulation PBS with no preservative; pH 7.2
Gene Klrk1
Gene Accession No. O54709
Gene Alias CD314; D12S2489E; D6H12S2489E; killer cell lectin like receptor K1; Killer cell lectin-like receptor subfamily K member 1; killer cell lectin-like receptor subfamily K, member 1; KLR; Klrk1; natural killer cell group 2D; natural killer cell receptor; NK cell receptor D; NK lectin-like receptor; Nkg2d; NKG2-D; NKG2-D type II integral membrane protein; NKG2-D-activating NK receptor; NKLLR; Nkrp2; NKR-P2; NKR-P2, ortholog of human NKG2D
Gene Symbols Klrk1
Host Species Rat
Purification Method Affinity chromatography
Quantity 5 mg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 27007
Target Species Mouse
Content And Storage 4°C
Product Type Antibody
Form Liquid
Isotype IgG1 κ
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Safety and Handling

WARNING: Cancer and Reproductive Harm - www.P65Warnings.ca.gov
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