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CD314 (NKG2D) Monoclonal Antibody (CX5), Functional Grade, eBioscience™, Invitrogen™

Rat Monoclonal Antibody

$253.00 - $502.65

Specifications

Antigen CD314 (NKG2D)
Clone CX5
Concentration 1 mg/mL
Applications Flow Cytometry, Functional Assay, Neutralization
Classification Monoclonal
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Products 3
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
50-145-98
Encompass_Preferred
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LIFE TECHNOLOGIES
16588282
100 μg
Each for $253.00
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50-145-99
Encompass_Preferred
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LIFE TECHNOLOGIES
16588285
500 μg
Each for $407.00
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16-588-286
Encompass_Preferred
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LIFE TECHNOLOGIES
16588286
1 mg
Each for $502.65

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Reg : $670.00

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Description

Description

Description: The CX5 monoclonal antibody reacts with the mouse NKG2D, a lectin-like molecule expressed on both human and mouse NK cells. Mouse NKG2D binds to retinoic acid-inducible RAE-1alpha, -beta, -gamma, -delta, -ε and the minor histocompatibility molecule H60 and has the ability to costimulate multiple NK activation receptors, through the DAP12/DAP10 adaptor molecules. NKG2D is expressed by all spleen and liver NK cells, NK1.1^+ thymocytes, in vitro activated LAK cells, and a subset of splenic NKT cells. Applications Reported: The CX5 antibody has been reported for use in flow cytometric analysis. It has also been reported in blocking of binding of NKG2D to its ligands, RAE-1 and H60, and inhibition NKG2D-dependent NK cell-mediated cytotoxicity against NKG2D ligand-bearing tumors in vitro and in vivo . Applications Tested: The CX5 antibody has been tested by flow cytometric analysis of mouse splenocytes. This can be used at less than or equal to 0.5 μg per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that when using this antibody for staining the secondary must be Biotin anti-rat (cat 13-4813). Other secondaries may give suboptimal staining.

Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. NK cells can regulate specific humoral and cell-mediated immunity, and preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. The NK gene encodes a member of the NKG2 family, and the encoded transmembrane protein is characterized by a type II membrane orientation (extracellular C terminus) and the presence of a C-type lectin domain. The NKG2 gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed in NK cells.
Specifications

Specifications

CD314 (NKG2D)
1 mg/mL
Monoclonal
Liquid
RUO
PBS with no preservative; pH 7.2
CD314; D12S2489E; D6H12S2489E; killer cell lectin like receptor K1; Killer cell lectin-like receptor subfamily K member 1; killer cell lectin-like receptor subfamily K, member 1; KLR; Klrk1; natural killer cell group 2D; natural killer cell receptor; NK cell receptor D; NK lectin-like receptor; Nkg2d; NKG2-D; NKG2-D type II integral membrane protein; NKG2-D-activating NK receptor; NKLLR; Nkrp2; NKR-P2; NKR-P2, ortholog of human NKG2D
Klrk1
Primary
4°C
Klrk1
CX5
Flow Cytometry, Functional Assay, Neutralization
Functional Grade
Rat
Mouse
O54709
27007
IgG1 κ
Affinity Chromatography
Antibody
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