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CD325 (N-Cadherin) Monoclonal Antibody (8C11), APC, eBioscience™, Invitrogen™

Mouse Monoclonal Antibody

$440.00

Specifications

Antigen CD325 (N-Cadherin)
Clone 8C11
Concentration 5 μL/Test
Applications Flow Cytometry
Classification Monoclonal
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Products 1
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
50-151-43
Encompass_Preferred
View Documents
Invitrogen™
17325942
100 Tests
Each of 1 for $440.00
Only null left
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Description

Description

Description: The 8C11 monoclonal antibody reacts with human CD325, also known as N-Cadherin. CD325 is a 130 kDa member of the Cadherin superfamily, and consists of five extracellular repeats, a transmembrane domain and a cytoplasmic domain. CD325 deficient mice die at day 10 of gestation and embryos display major heart defects and malformed neural tubes and somites. Consistent with this, CD325 has been implicated in several aspects of cardiac development including the precardiac mesoderm, establishment of left-right symmetry and cardiac looping morphogenesis. Furthermore, CD325 is normally involved in inducing cell cycle arrest and its expression is frequently dysregulated in cancer cells. Applications Reported: This 8C11 antibody has been reported for use in flow cytometric analysis. Applications Tested: This 8C11 antibody has been pre-titrated and tested by flow cytometric analysis of the HeLa cell line. This can be used at 5 μL (0.25 μg) per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. Excitation: 633-647 nm; Emission: 660 nm; Laser: Red Laser. Filtration: 0.2 μm post-manufacturing filtered.

N-cadherin is a 140 kDa protein belonging to a family of transmembrane molecules that mediate calcium-dependent intercellular adhesion. Cadherins are involved in controlling morphogenetic movements during development and regulate cell surface adhesion through homotypic adhesion with the same cadherin species. N-cadherin's function is dependent on its association with the actin-cytoskeleton and is mediated through interactions between the C-terminal region of N-cadherin and the cytoplasmic catenin proteins. The stability of this association is regulated by phosphorylation and dephosphorylation of beta-catenin. Further, N-cadherin is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. The protein functions during gastrulation and is required for establishment of left-right asymmetry.
Specifications

Specifications

CD325 (N-Cadherin)
5 μL/Test
Monoclonal
Liquid
RUO
P19022
CDH2
Primary
4°C, store in dark, DO NOT FREEZE!
CDH2
8C11
Flow Cytometry
APC
Mouse
Human
1000
IgG1 κ
Affinity Chromatography
Antibody
Videos
SDS
Documents

Documents

Product Certifications

For Research Use Only.

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