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Invitrogen™ CD335 (NKp46) Monoclonal Antibody (VIV-KM1), APC
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Catalog No. PIMA528352
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100 Tests
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PIMA528352 100 Tests
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Catalog No. PIMA528352 Supplier Invitrogen™ Supplier No. MA528352
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Description

Mouse Monoclonal Antibody

This antibody recognizes ovine and caprine CD335. Reconstitute with 1.0 mL distilled water.

CD335, also known as NKp46 or NCR1, is a member of the natural cytotoxicity receptor family, which includes NKp30 and NKp44. This type I transmembrane glycoprotein is expressed on NK cells and plays a crucial role in activating and expanding resting NK cells through interactions with dendritic cells. CD335 enhances the ability of NK cells to eliminate tumor and virus-infected cells, such as those infected by influenza. CD335 consists of two Ig-like domains and is related to leukocyte immunoglobulin-like receptors (LIR) and killer inhibitory receptors (KIR). It contributes to the increased efficiency of activated NK cells in mediating tumor cell lysis. Additionally, CD335 interacts with pancreatic beta cells during the development of type 1 diabetes, highlighting its involvement in both immune defense and autoimmune processes.
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Specifications

Antigen CD335 (NKp46)
Applications Flow Cytometry
Classification Monoclonal
Clone VIV-KM1
Concentration Conc. Not Determined
Conjugate APC
Formulation PBS with 5% sucrose, 1% BSA and 0.09% sodium azide
Gene NCR1
Gene Accession No. 0
Gene Alias 1-Mar; activating receptor 1; Ar1; CD335; hNKp46; Kilr1; KILR-1; LY94; Ly-94; lymphocyte antigen 94; Lymphocyte antigen 94 homolog; lymphocyte antigen 94 homolog (activating NK-receptor; lymphocyte antigen 94 homolog (activating NK-receptor; NK-p46); mAR-1; MAR1 (mouse activating receptor 1); mNKp46; natural cytotoxicity triggering receptor 1; Natural killer cell p46-related protein; natural killer cell receptor; Ncr1; NK cell-activating receptor; NK receptor KILR-1; NKACTR; Nkp46; NK-p46; NK-p46); rAR-1; rat-activating receptor 1
Gene Symbols NCR1
Host Species Mouse
Immunogen Fusion protein consisting of the extracellular region of porcine CD335.
Purification Method Protein A
Quantity 100 Tests
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 100141419
Target Species Pig
Content And Storage 4°C, store in dark, DO NOT FREEZE!
Product Type Antibody
Form Lyophilized
Isotype IgG1
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