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CD335 (NKp46) Rat anti-Mouse, Functional Grade, Clone: 29A1.4, eBioscience™ Non-distribution product as customer accommodation.

Rat Monoclonal Antibody

$161.00 - $398.00

Specifications

Antigen CD335 (NKp46)
Clone 29A1.4
Target Species Mouse
Conjugate Functional Grade
Isotype IgG2a, kappa
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Products 2
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
50-145-20 Non-distribution product as customer accommodation.
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Invitrogen
16335181
50 μg
Each for $161.00
Add to cart
 
50-145-21 Non-distribution product as customer accommodation.
View Documents
Invitrogen
16335185
500 μg
Each for $398.00
Add to cart
 
Description

Description

Description: The monoclonal antibody 29A1.4 recognizes mouse NKp46, also known as CD335. CD335, a member of the natural cytotoxicity receptor (NCR) family, is a glycoprotein with 2 Ig-like domains and a short cytoplasmic tail. Expression of CD335 is uniquely found on NK cells (including immature NK cells, defined as DX5- CD3-, and thereby allowing discrimination between NKT cells and NK cells (NKp46+, CD3-). Furthermore, unlike many of the NK markers which also stain NKT cells, staining with 29A1.4 is not strain specific. Staining has been shown on C57Bl/6, SJL, CBA/CA and BALB/C strains. NKp46 has been shown to play a role in NK cell-mediated lysis of several tumor cells and pathogen-infected cell lines. The 29A1.4 monoclonal antibody has been shown to activate NK cells in vitro. The 29A1.4 monoclonal antibody does not deplete NK cells in vivo. Applications Reported: This 29A1.4 antibody has been reported for use in flow cytometric analysis. Applications Tested: This 29A1.4 antibody has been tested by flow cytometric analysis of mouse splenocytes. This can be used at less than or equal to 1 µg per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. Endotoxin: Less than 0.

001 ng/ug antibody as determined by the LAL assay. Storage and handling: Use in a sterile environment. Filtration: 0.2 µm post-manufacturing filtered. Purity: Greater than 90%, as determined by SDS-PAGE. Endotoxin Level: Less than 0.001 ng/µg antibody, as determined by LAL assay. Aggregation: Less than 10%, as determined by HPLC. Cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis.
Specifications

Specifications

CD335 (NKp46)
Mouse
IgG2a, kappa
Monoclonal
Liquid
Antibody
4° C
29A1.4
Functional Grade
Flow Cytometry, Functional Assay
Primary
Monoclonal
PBS with no preservative; pH 7.2
RUO
SDS

For Research Use Only.

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