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CD339 (Jagged 1) Monoclonal Antibody (HMJ1-29), PE, eBioscience™, Invitrogen™

Armenian Hamster Monoclonal Antibody

$210.00 - $420.00

Specifications

Antigen CD339 (Jagged 1)
Clone HMJ1-29
Concentration 0.2 mg/mL
Applications Flow Cytometry
Classification Monoclonal
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Products 2
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
50-107-62
Encompass_Preferred
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Invitrogen™
12339180
25 μg
Each for $210.00
Only null left
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50-107-63
Encompass_Preferred
View Documents
Invitrogen™
12339182
100 μg
Each for $420.00
Only null left
Edge
Add to Cart
 
Description

Description

Description: This HMJ1-29 monoclonal antibody reacts with mouse Jagged-1, one of five type I transmembrane proteins that serves as a Notch receptor ligand. Upon binding the Notch receptor (e.g. Notch 1-4), Jagged-1 undergoes proteolytic cleavage, first by ADAM-family metalloproteases and then by gamma-secretase. The second cleavage event releases an intracellular fragment whose biological function remains controversial. Jagged-1 is expressed by thymic lymphoid and stromal cells, as well as macrophages and CD8+CD11c+ dendritic cells in the spleen. The HMJ1-29 antibody is reported to crossreact to rat. Applications Reported: This HMJ1-29 antibody has been reported for use in flow cytometric analysis. Applications Tested: This HMJ1-29 antibody has been tested by flow cytometric analysis of mouse splenocytes. This can be used at less than or equal to 1 μg per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. Excitation: 488-561 nm; Emission: 578 nm; Laser: Blue Laser, Green Laser, Yellow-Green Laser. Filtration: 0.2 μm post-manufacturing filtered.

The jagged 1 protein encoded by JAG1 is the human homolog of the Drosophilia jagged protein. Human jagged 1 is the ligand for the receptor notch 1, the latter a human homolog of the Drosophilia jagged receptor notch. Mutations that alter the jagged 1 protein cause Alagille syndrome. Jagged 1 signalling through notch 1 has also been shown to play a role in hematopoiesis.
Specifications

Specifications

CD339 (Jagged 1)
0.2 mg/mL
Monoclonal
Liquid
RUO
PBS with 0.09% sodium azide; pH 7.2
ABE2; AGS; AHD; AWS; CD339; Gsfabe2; HJ1; Htu; JAG1; jagged 1; jagged canonical Notch ligand 1; Jagged1; JAGL1; Ozz; protein jagged-1; Ser-1; Serrate-1
JAG1
Primary
4°C, store in dark, DO NOT FREEZE!
JAG1
HMJ1-29
Flow Cytometry
PE
Armenian Hamster
Mouse, Rat
Q63722, Q9QXX0
16449, 29146
IgG
Affinity chromatography
Antibody
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