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CD366 (TIM3) Monoclonal Antibody (8B.2C12), Alexa Fluor™ 488, eBioscience™, Invitrogen™
Rat Monoclonal Antibody
$173.00 - $353.60
Specifications
| Antigen | CD366 (TIM3) |
|---|---|
| Clone | 8B.2C12 |
| Concentration | 0.5 mg/mL |
| Applications | Flow Cytometry |
| Classification | Monoclonal |
| Catalog Number | Mfr. No. | Quantity | Price | Quantity & Availability | |||||
|---|---|---|---|---|---|---|---|---|---|
| Catalog Number | Mfr. No. | Quantity | Price | Quantity & Availability | |||||
53-587-180
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Invitrogen
53587180 |
25 μg |
Each for $173.00
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53-587-182
|
Invitrogen
53587182 |
100 μg |
Each
for $353.60
Save 15% Reg : |
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Description
TIM3 (Hepatitis A virus cellular receptor 2, HAVCR2, T-cell immunoglobulin, mucin-dmain containing-3) is a 281 amino acid long, Type-1 Th1- specific cell surface glycoprotein expressed on terminally differentiated CD4+Th1 and CD8+Tc1 cells. TIM3 consists of an IgV-like domain, a mucin-like domain in the extracellular region, and a conserved Tyrosine phosphorylation motif in the cytoplasmic region. TIM3 is involved in macrophage activation and induction of autoimmune diseases. Further, TIM3 down-regulates aggressive Th1-mediated immune responses and facilitates in the development of immune tolerance. Pathological significance of TIM3 has been attributed to Experimental autoimmune encephalomyelitis (EAE), a Th-1 dependent autoimmune disease, and also enhances the severity of experimental autoimmune encephalomyelitis in mice.Specifications
| CD366 (TIM3) | |
| 0.5 mg/mL | |
| Monoclonal | |
| Liquid | |
| RUO | |
| PBS with 0.09% sodium azide; pH 7.2 | |
| CD366; FLJ14428; Havcr2; HAVcr-2; Hepatitis A virus cellular receptor 2; hepatitis A virus cellular receptor 2 homolog; kidney injury molecule-3; KIM-3; sCD366; soluble CD366; soluble TIM 3; T cell immunoglobulin mucin 3; T cell immunoglobulin mucin-3; T-cell immunoglobulin and mucin domain containing 3; T-cell immunoglobulin and mucin domain-containing protein 3; T-cell immunoglobulin mucin family member 3; T-cell immunoglobulin mucin receptor 3; T-cell membrane protein 3; Tim3; TIM-3; TIMD3; TIMD-3 | |
| Havcr2 | |
| Primary | |
| 4° C, store in dark, DO NOT FREEZE! | |
| Havcr2 |
| 8B.2C12 | |
| Flow Cytometry | |
| Alexa Fluor 488 | |
| Rat | |
| Mouse | |
| Q8VIM0 | |
| 171285 | |
| IgG1 κ | |
| Affinity chromatography | |
| Antibody |
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