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  6. Invitrogen™ CD366 (TIM3) Monoclonal Antibody (8B.2C12), APC-eFluor™ 780, eBioscience™, Invitrogen™ 

Invitrogen™ CD366 (TIM3) Monoclonal Antibody (8B.2C12), APC-eFluor™ 780, eBioscience™, Invitrogen™
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Catalog No. 47587182
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100 μg
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Catalog No. Quantity
47-587-182 100 μg
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Catalog No. 47-587-182 Supplier Invitrogen™ Supplier No. 47587182
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Description

Rat Monoclonal Antibody

The 8B.2C12 monoclonal antibody reacts with mouse CD366 (TIM3), a Th1-specific cell surface protein. CD366 is a type I transmembrane protein and contains an immunoglobulin and a mucin-like domain in its extracellular portion and a tyrosine phosphorylation

TIM3 (Hepatitis A virus cellular receptor 2, HAVCR2, T-cell immunoglobulin, mucin-dmain containing-3) is a 281 amino acid long, Type-1 Th1- specific cell surface glycoprotein expressed on terminally differentiated CD4+Th1 and CD8+Tc1 cells. TIM3 consists of an IgV-like domain, a mucin-like domain in the extracellular region, and a conserved Tyrosine phosphorylation motif in the cytoplasmic region. TIM3 is involved in macrophage activation and induction of autoimmune diseases. Further, TIM3 down-regulates aggressive Th1-mediated immune responses and facilitates in the development of immune tolerance. Pathological significance of TIM3 has been attributed to Experimental autoimmune encephalomyelitis (EAE), a Th-1 dependent autoimmune disease, and also enhances the severity of experimental autoimmune encephalomyelitis in mice.
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Specifications

Antigen CD366 (TIM3)
Applications Flow Cytometry
Classification Monoclonal
Clone 8B.2C12
Concentration 0.2 mg/mL
Conjugate APC-eFluor 780
Formulation PBS with 0.09% sodium azide; pH 7.2
Gene Havcr2
Gene Accession No. Q8VIM0
Gene Alias CD366; FLJ14428; Havcr2; HAVcr-2; Hepatitis A virus cellular receptor 2; hepatitis A virus cellular receptor 2 homolog; kidney injury molecule-3; KIM-3; sCD366; soluble CD366; soluble TIM 3; T cell immunoglobulin mucin 3; T cell immunoglobulin mucin-3; T-cell immunoglobulin and mucin domain containing 3; T-cell immunoglobulin and mucin domain-containing protein 3; T-cell immunoglobulin mucin family member 3; T-cell immunoglobulin mucin receptor 3; T-cell membrane protein 3; Tim3; TIM-3; TIMD3; TIMD-3
Gene Symbols Havcr2
Host Species Rat
Purification Method Affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 171285
Target Species Mouse
Content And Storage 4°C, store in dark, DO NOT FREEZE!
Product Type Antibody
Form Liquid
Isotype IgG1 κ
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