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AdipoGen CD40L ms multimeric rec
SDP

Supplier:  AdipoGen AG40B0020C010

Encompass_Preferred

Protein. Mouse CD40L aa 115-260 is fused at the N-terminus to mouse ACRP30headless aa 18-111 and a FLAG -tag. Source CHO cells. Endotoxin content <0.01EU/µg purified protein LAL test Lonza. Lyophilized. Contains PBS. Binds to human and mouse CD40. Purity >95% SDS-PAGE. MultimericCD40L™ is a high activity construct in which two trimeric CD40 ligands are artificially linked via the collagen domain of ACRP30. This construct very effectively simulates the natural membrane-assisted aggregation of CD40L in vivo. It provides a simple and equally potent alternative to CD40Lenhancer combinations. MultimericCD40L™ has shown to suppress alum-induced IL-1beta release and caspase-1 activation in a dose-, CD40- and time dependent manner, without affecting BMDM Bone marrow-derived macrophages viability. It also effectively suppressed the inflammasome function triggered by NLRP3 activators.

Catalog No. 50-256-2935


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