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Invitrogen™ CD50 (ICAM3) Biosimilar Recombinant Monoclonal Antibody

Catalog No. MA559348
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100 μg
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MA559348 1 mg
MA559347 100 μg
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Catalog No. MA559348 Supplier Invitrogen™ Supplier No. MA559348
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Description

Recombinant Monoclonal Antibody

For reconstitution, add sterile, distilled water to achieve a final antibody concentration of 1 mg/mL. Gently shake to solubilize the protein completely. Do not vortex. Reconstituted products should be stored at -80 °. This antibody can also be cross referenced by the term Forerunner patent anti-ICAM-3.

CD50 (intracellular adhesion molecule 3, ICAM-3) is a transmembrane glycoprotein expressed by leukocytes, that serves as a counter-receptor for the lymphocyte function-associated antigen (LFA)-1 integrin. Besides functioning as an adhesive molecule that mediates e.g. the contact between T cells and antigen presenting cells, ICAM-3 regulates affinity of LFA-1 for ICAM-1 and induces T cell activation and proliferation. ICAM-3 plays an essential role in the initiation of the immune response both on T cells and antigen presenting cells and interacts also with CD209 (dendritic cell-specific ICAM-3-grabbing nonintegrin, DC-SIGN), a C-type lectin of dendritic cells and macrophages; this process is involved in dialogue between dendritic cells and granulocytes.
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Specifications

Antigen CD50 (ICAM3) Chimeric Biosimilar
Applications ELISA, Flow Cytometry, Functional Assay, Surface Plasmon Resonance
Classification Recombinant Monoclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation 25mM histidine with 8% sucrose, 0.01% Tween 80 and no preservative; pH 6.2
Host Species Human
Purification Method Protein A
Quantity 1 mg
Regulatory Status RUO
Primary or Secondary Primary
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Lyophilized
Isotype IgG1
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