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Invitrogen™ CD56 Monoclonal Antibody (RNL-1)
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Catalog No. MA106800
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MA106800 100 μL
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Catalog No. MA106800 Supplier Invitrogen™ Supplier No. MA106800
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Description

Mouse Monoclonal Antibody

MA1-06800 detects NCAM in human and mouse samples. MA1-06800 has sucessfully been used in immunohistochemistry and immunocytochemistry procedures. The MA1-06800 immunogen is a membrane preparation of the small cell lung cancer cell line NCI-H82. Store at 4°C or in small aliquots at -20°C.

CD56, also known as neural cell adhesion molecule (NCAM), is a highly glycosylated transmembrane glycoprotein of the immunoglobulin family. It plays a crucial role in cell adhesion, migration, axonal growth, pathfinding, and synaptic plasticity. CD56 is ubiquitously expressed in the nervous system in isoforms ranging from 120-180 kDa and is involved in homotypic adhesion of neural cells. It mediates interactions by binding extracellular matrix components such as laminin and integrins, with polysialic modification reducing CD56-mediated adhesion. In the hematopoietic system, CD56 is expressed on natural killer (NK) cells and a subset of T cells known as NKT cells. It is also found on most neuroectodermal-derived cell lines, tissues, and neoplasms, including retinoblastoma, medulloblastoma, astrocytomas, and neuroblastoma. CD56 serves as a widely used neuroendocrine marker with high sensitivity for neuroendocrine tumors and ovarian granulosa cell tumors. Diseases associated with CD56 dysfunction include rabies and blastic plasmacytoid dendritic cell neoplasms, highlighting its importance in both neural and immune system functions.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CD56
Applications Immunohistochemistry (Frozen), Immunocytochemistry
Classification Monoclonal
Clone RNL-1
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.09% sodium azide
Gene Ncam1
Gene Accession No. P13591, P13595
Gene Alias adhesion molecule; antigen recognized by monoclonal antibody 5.1H11; Cd56; CD-56; CD56 120 kDa GPI-linked isoform; CD56 140 kDa isoform; CD56 140 kDa VASE isoform; E NCAM; E-NCAM; MSK39; N CAM1; NCAM; N-CAM; Ncam1; N-CAM-1; NCAM-1; NCAMC; NCAM-C; neural cell adhesion molecule; Neural cell adhesion molecule 1; neural cell adhesion molecule, NCAM; sCD56; sNCAM; soluble CD56; soluble NCAM
Gene Symbols Ncam1
Host Species Mouse
Immunogen Small cell lung cancer cell line NCI-H82.
Purification Method Purified
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 17967, 4684
Target Species Human, Mouse
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG1
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Safety and Handling

WARNING: Reproductive Harm - www.P65Warnings.ca.gov
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