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Invitrogen™ CD6 Monoclonal Antibody (MEM-98)
Mouse Monoclonal Antibody
Supplier: Invitrogen™ MA119078
Description
This antibody reacts with an extracellular epitope of CD6, a 100-130 kDa single chain transmembrane glycoprotein expressed on T and B lymphocytes subsets, thymocytes, and acute lymphocytic leukemia cells. Western Blot: non-reducing conditions.
CD6, also known as T12, is a member of the scavenger receptor superfamily found on T and B cell subsets, thymocytes, and acute lymphocytic leukemia cells (ALL). CD6 interacts with its ligand CD166/ALCAM (activated leukocyte cell adhesion molecule) and serves as a coreceptor for T cell activation and stabilizer of the immunological synapse. CD6-ALCAM mediated cell adhesion is also important for T cell proliferation. CD6 may exert some its functions via association with CD5, probably by fine-tuning CD5 signaling. Ligation of CD6 has antiapoptotic role in chronic lymphocytic leukemia B cells.
Specifications
CD6 | |
Monoclonal | |
1 mg/mL | |
PBS with 15mM sodium azide; pH 7.4 | |
P30203 | |
CD6 | |
Human CD6 antigen purified by immunoaffinity chromatography from HBP-ALL cells followed by preparative SDS-PAGE of non-boiled non-reduced sample (excised piece of gel corresponding to the 100 kDa zone) (aa 125-128). | |
100 μg | |
Primary | |
Human | |
Antibody | |
IgG1 |
Flow Cytometry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot | |
MEM-98 | |
Unconjugated | |
CD6 | |
Cd6; CD6 antigen; CD6 antigen, Tp120; Cd6 molecule; FLJ44171; OX52; Soluble CD6; T12; T-cell differentiation antigen CD6; TP120 | |
Mouse | |
Protein A | |
RUO | |
923 | |
4°C, do not freeze | |
Liquid |
Safety and Handling
WARNING: Cancer - www.P65Warnings.ca.gov
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