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Invitrogen™ CD6 Monoclonal Antibody (MEM-98)
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Catalog No. 01675050
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100 μg
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Catalog No. Quantity
01-675-050 100 μg
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Catalog No. 01-675-050 Supplier Invitrogen™ Supplier No. MA119078
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Description

Mouse Monoclonal Antibody

This antibody reacts with an extracellular epitope of CD6, a 100-130 kDa single chain transmembrane glycoprotein expressed on T and B lymphocytes subsets, thymocytes, and acute lymphocytic leukemia cells. Western Blot: non-reducing conditions.

CD6, also known as T12, is a member of the scavenger receptor superfamily found on T and B cell subsets, thymocytes, and acute lymphocytic leukemia cells (ALL). CD6 interacts with its ligand CD166/ALCAM (activated leukocyte cell adhesion molecule) and serves as a coreceptor for T cell activation and stabilizer of the immunological synapse. CD6-ALCAM mediated cell adhesion is also important for T cell proliferation. CD6 may exert some its functions via association with CD5, probably by fine-tuning CD5 signaling. Ligation of CD6 has antiapoptotic role in chronic lymphocytic leukemia B cells.
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Specifications

Antigen CD6
Applications Flow Cytometry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Classification Monoclonal
Clone MEM-98
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 15mM sodium azide; pH 7.4
Gene CD6
Gene Accession No. P30203
Gene Alias Cd6; CD6 antigen; CD6 antigen, Tp120; Cd6 molecule; FLJ44171; OX52; Soluble CD6; T12; T-cell differentiation antigen CD6; TP120
Gene Symbols CD6
Host Species Mouse
Immunogen Human CD6 antigen purified by immunoaffinity chromatography from HBP-ALL cells followed by preparative SDS-PAGE of non-boiled non-reduced sample (excised piece of gel corresponding to the 100 kDa zone) (aa 125-128).
Purification Method Protein A
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 923
Target Species Human
Content And Storage 4°C, do not freeze
Product Type Antibody
Form Liquid
Isotype IgG1
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