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CD61 Monoclonal Antibody (CRC54), Invitrogen™

Catalog No. 01671227
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Catalog No. Quantity
01-671-227 1 mL
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Catalog No. 01-671-227 Supplier Thermo Scientific Supplier No. MA135264

Description

Mouse Monoclonal Antibody

Reconstitute with 1 mL of distilled water.

CD61 (GPIIIa, ITGB3) is a glycoprotein found on megakaryocytes, platelets and their precursors. CD61 antigen plays a role in platelet aggregation and also as a receptor for fibrinogen, fibronectin, von Willebrand factor and vitronectrin. CD61 is a 105 kDa glycoprotein that associates with either the alpha 11b integrin (CD41) or the alpha V integrin (CD51) at the cell surface. CD61 is expressed on platelets and megakaryocytes in association with CD41, and on endothelial cells, monocytes, platelets and osteoclasts in association with CD51. CD61 is a receptor for fibrinogen, fibronectin, Von Willebrand Factor, vitronectin and thrombospondin. The CD61 protein product is composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. CD61 is found along with the alpha IIb chain in platelets. Like other integrins, CD61 is known to participate in cell adhesion as well as cell-surface mediated signaling. Diseases associated with CD61 dysfunction include Glanzmann Thrombasthenia and Platelet type-16 Bleeding Disorder.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CD61
Applications Immunohistochemistry (Frozen)
Classification Monoclonal
Clone CRC54
Concentration 0.2 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.09% sodium azide
Gene ITGB3
Gene Accession No. P05106
Gene Alias antigen CD61; BDPLT16; BDPLT2; beta3 integrin; CD61; EGK_08849; glycoprotein GPIIIa; glycoprotein IIIa; GP3A; GPIIIa; GT; INGRB3; integrin beta 3; integrin beta 3 (Cd61); integrin beta-3; integrin beta-3 subunit; integrin subunit beta 3; integrin, beta 3; integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61); ITGB3; platelet glycoprotein IIIa; platelet glycoprotein IIIa integrin subunit beta 3; platelet gpIIIa; platelet membrane glycoprotein IIIa
Gene Symbols ITGB3
Host Species Mouse
Immunogen CD61.
Purification Method purified
Quantity 1 mL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 3690
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Lyophilized
Isotype IgG1 κ
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