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CD61 Mouse Anti-Rat, Brilliant Violet 786, Clone: F11, BD Optibuild™

Catalog No. BDB744460 Shop All BD Biosciences Products
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BDB744460 50 μg
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Description

Mouse Monoclonal Antibody

The F11 monoclonal antibody specifically recognizes integrin 3 chain (CD61), which associates with the integrin v chain (CD51), to form the vitronectin receptor found on endothelial cells, myeloid cells, and osteoclasts, and with the IIb chain (CD41) on platelets and megakaryocytes. Both receptors mediate adhesion to fibronectin, fibrinogen, vitronectin, thrombospondin, and von Willebrand factor. The F11 antibody reportedly blocks the in vitro attachment of osteoclasts to several ligands. Weak F11 antibody reactivity with human osteoclasts, megakaryocytes, and platelets has also been reported.

The antibody was conjugated to BD Horizon™ BV786 which is part of the BD Horizon Brilliant™ Violet family of dyes. This dye is a tandem fluorochrome of BD Horizon BV421 with an Ex Max of 405nm and an acceptor dye with an Em Max at 786nm. BD Horizon BV786 can be excited by the violet laser and detected in a filter used to detect Cy™7-like dyes (eg, 780/60nm filter). BV786 is a tandem fluorochrome of BD Horizon BV421 and an acceptor dye with an emission maximum at 786 nm. BV786 offers a bright choice for the 6th detector off the violet laser.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CD61
Classification Monoclonal
Clone F11
Concentration 0.2mg/mL
Conjugate Brilliant Violet 786
Formulation Aqueous buffered solution containing ≤0.09% sodium azide.
Gene Alias Integrin β3 chain, Itgb3, Integrin beta-3
Host Species Mouse
Immunogen Rat (Sprague-Dawley) bone cell suspensions
Purification Method Affinity Purified
Quantity 50 μg
Regulatory Status RUO
Primary or Secondary Primary
Target Species Mouse
Content And Storage Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Isotype IgG1 κ
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Safety and Handling

WARNING: Reproductive Harm - www.P65Warnings.ca.gov
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