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Invitrogen™ CD68 Monoclonal Antibody (514H12)
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Catalog No. MA180133
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100 μL
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MA180133 100 μL
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Catalog No. MA180133 Supplier Invitrogen™ Supplier No. MA180133
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Description

Mouse Monoclonal Antibody

Heat-mediated antigen retrieval using Tris/EDTA (pH 8) is recommended for the staining of paraffin sections. The epitope recognized by clone 514H12 is sensitive to peroxide and so any peroxidase-blocking steps should be performed after incubation with this antibody. A suggested positive control for immunohistochemical applications is human tonsil. Mouse anti Human CD68 antibody, clone 514H12 recognizes the human CD68 cell surface antigen, a approximately 110 kDa glycoprotein primarily expressed by macrophages and monocytes.

CD68 (Macrosialin) is a 110 kDa integral membrane glycoprotein predominantly expressed on the intracellular lysomsomes of monocytes and macrophages and to a lesser extent by dendritic cells and peripheral blood granulocytes. Also, CD68 could play a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. CD68 is expressed by interdigitating reticulum cells in tonsil and some histiocytic lymphoma or histiocytosis, acute myeloid leukemia (AML), and granulocytic sarcoma. Elevated expression of CD68 has been demonstrated on CD34+ cells in various human malignancies, including several Acute Myeloid Leukemia studies.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CD68
Applications Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Immunocytochemistry
Classification Monoclonal
Clone 514H12
Concentration Conc. Not Determined
Conjugate Unconjugated
Formulation Tissue culture supernatant with <0.1% sodium azide
Gene Cd68
Gene Accession No. P34810
Gene Alias CD68; CD68 antigen; CD68 molecule; GP110; Lamp4; macrophage antigen CD68; macrosialin; Scard1; scavenger receptor class D, member 1; similar to CD68 antigen
Gene Symbols Cd68
Host Species Mouse
Immunogen Fusion protein of external domain of human CD68.
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 968
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG2a
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Safety and Handling

WARNING: Reproductive Harm - www.P65Warnings.ca.gov
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