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Invitrogen™ CD68 Monoclonal Antibody (ED1), PE
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Catalog No. PIMA516653
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100 Tests
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PIMA516653 100 Tests
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Catalog No. PIMA516653 Supplier Invitrogen™ Supplier No. MA516653
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Description

Mouse Monoclonal Antibody

Membrane permeabilization is required for flow cytometry applications. For FACS analysis, use 10 μL of the suggested working dilution to label 1x10^6 cells in 100 μL. Reconstitute with 1 mL of distilled water. After reconstitution, store product undiluted at 4°C in the dark. Mouse anti rat CD68, clone ED1 recognizes the rat ED1 antigen, a heavily glycosylated protein of approximately 90 -110 KDa, also known as rat CD68 (Dijkstra et al. 1985).

CD68 (Macrosialin) is a 110 kDa integral membrane glycoprotein predominantly expressed on the intracellular lysomsomes of monocytes and macrophages and to a lesser extent by dendritic cells and peripheral blood granulocytes. Also, CD68 could play a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. CD68 is expressed by interdigitating reticulum cells in tonsil and some histiocytic lymphoma or histiocytosis, acute myeloid leukemia (AML), and granulocytic sarcoma. Elevated expression of CD68 has been demonstrated on CD34+ cells in various human malignancies, including several Acute Myeloid Leukemia studies.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CD68
Applications Flow Cytometry
Classification Monoclonal
Clone ED1
Concentration Conc. Not Determined
Conjugate PE
Formulation PBS with 1% BSA and 0.09% sodium azide
Gene Cd68
Gene Accession No. 0
Gene Alias CD68; CD68 antigen; CD68 molecule; GP110; Lamp4; macrophage antigen CD68; macrosialin; Scard1; scavenger receptor class D, member 1; similar to CD68 antigen
Gene Symbols Cd68
Host Species Mouse
Immunogen Rat spleen cells.
Purification Method Protein A
Quantity 100 Tests
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 287435, 504960
Target Species Rat, Bovine
Content And Storage 4°C, store in dark, DO NOT FREEZE!
Product Type Antibody
Form Lyophilized
Isotype IgG1
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