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Invitrogen™ CD7 Monoclonal Antibody (LT7)

Catalog No. p-7171202
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Quantity:
200 μg
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Catalog No. Quantity
PIMA134142 200 μg
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Catalog No. PIMA134142 Supplier Invitrogen™ Supplier No. MA134142

Description

Mouse Monoclonal Antibody

CD7 Monoclonal Antibody for IHC (F), Flow, IP

CD7, also known as gp40 or Leu9, is a 40 kDa receptor and member of the immunoglobulin gene superfamily. It features an N-terminal region (amino acids 1-107) that is highly homologous to Ig kappa light chains, while its carboxyl-terminal region is proline-rich, forming a stalk from which the Ig domain projects. CD7 is prominently expressed on the majority of immature and mature T lymphocytes, as well as T cell leukemias. It is also found on natural killer cells, a small subpopulation of normal B cells, and malignant B cells. CD7 plays a crucial role in modulating immune cell activity. Cross-linking of surface CD7 enhances T cell and NK cell functions, as evidenced by increased calcium flux, expression of adhesion molecules, cytokine secretion, and proliferation. CD7 directly associates with phosphoinositol 3-kinase, and its ligation induces the production of D-3 phosphoinositides and tyrosine phosphorylation. The expression of CD7 is an important marker in leukemia diagnostics, highlighting its significance in both normal immune function and disease states.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CD7
Applications Flow Cytometry, Immunohistochemistry (Frozen), Immunoprecipitation
Classification Monoclonal
Clone LT7
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.09% sodium azide
Gene CD7
Gene Accession No. P09564
Gene Alias Cd7; CD7 antigen; CD7 antigen (p41); Cd7 molecule; GP40; LEU-9; p41 protein; T-cell antigen CD7; T-cell leukemia antigen; T-cell surface antigen Leu-9; Tp40; TP41
Gene Symbols CD7
Host Species Mouse
Immunogen Normal human peripheral blood lymphocytes.
Purification Method Protein A
Quantity 200 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 924
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG2a
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