Invitrogen™ CD72 Monoclonal Antibody (10.1.D2), PE

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MMCD72104

Catalog No. 50-113-7534

Description

CD72 Monoclonal Antibody for Flow

CD72 is a transmembrane glycoprotein expressed as a homodimer especially in B cells, but also in other antigen presenting cells such as dendritic cells and macrophages. Through one of its immunoreceptor tyrosine-based inhibitory motives (ITIMs), CD72 interacts with tyrosine phosphatase SHP-1, thereby suppressing B cell responsiveness. Binding of CD72 with its ligand CD100 (Sema4D) prevents BCR association and phosphorylation of CD72 and results in dissociation of SHP-1 from CD72, thus enables B cell activation.

Specifications

• Antigen: CD72
• Classification: Monoclonal
• Concentration: 0.1 mg/mL
• Formulation: PBS with <0.1% sodium azide; pH 7.5
• Gene Accession No.: P21855
• Gene Symbols: CD72
• Immunogen: Mouse CD72.1 (Lyb-2.1). from DBA/2 mouse spleen cells.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Mouse
• Product Type: Antibody
• Isotype: IgG2b κ

• Applications: Flow Cytometry
• Clone: 10.1.D2
• Conjugate: PE
• Gene: CD72
• Gene Alias: B-cell differentiation antigen CD72; CD72; CD72 antigen; Cd72 molecule; CD72b; CD72c; Ly-19; Ly32; Ly-32; LYB2; Lyb-2; Ly-m19; lymphocyte antigen 32; RP11-331F9.9
• Host Species: Mouse
• Purification Method: Purified
• Regulatory Status: RUO
• Gene ID (Entrez): 12517
• Content And Storage: 4°C, store in dark, DO NOT FREEZE!
• Form: Liquid