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  6. Invitrogen™ CD73 Monoclonal Antibody (eBioTY/11.8 (TY/11.8)), Super Bright™ 702, eBioscience™, Invitrogen™ 

Invitrogen™ CD73 Monoclonal Antibody (eBioTY/11.8 (TY/11.8)), Super Bright™ 702, eBioscience™, Invitrogen™
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Catalog No. p-7193245
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Catalog No. Quantity
67-073-182 100 μg
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Catalog No. 67-073-182 Supplier Invitrogen™ Supplier No. 67073182
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Description

Rat Monoclonal Antibody

CD73, also known as Ecto-5-prime-nucleotidase or 5-prime-ribonucleotide phosphohydrolase, is an enzyme that catalyzes the conversion of purine 5-prime mononucleotides to nucleosides at neutral pH, with AMP as its preferred substrate. It is composed of a dimer of two identical 70 kDa subunits, externally bound to the plasma membrane via a glycosyl phosphatidyl inositol linkage. CD73 serves as a marker of lymphocyte differentiation and is expressed on a subset of lymphocytes, increasing during lymphocyte maturation. It is found on memory CD4 T cells, which resemble uncommitted primed precursor helper cells (Thpp) capable of differentiating into Th1 or Th2 cells, and is also present on regulatory T cells. CD73 deficiency is associated with various immunodeficiency diseases. Other forms of 5-prime nucleotidase exist in the cytoplasm and lysosomes, distinguishable from CD73 by their substrate affinities, requirement for divalent magnesium ions, activation by ATP, and inhibition by inorganic phosphate. The CD73 gene is localized to chromosome 6q14-q21, and defects in this gene can lead to conditions such as calcification of joints and arteries, and intestinal tuberculosis. Additionally, two transcript variants encoding different isoforms of CD73 have been identified.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CD73
Applications Flow Cytometry
Classification Monoclonal
Clone eBioTY/11.8 (TY/11.8)
Concentration 0.2 mg/mL
Conjugate Super Bright 702
Formulation PBS with BSA and 0.09% sodium azide; pH 7.2
Gene NT5E
Gene Accession No. Q61503
Gene Alias 2210401F01Rik; 5 nucleotidase, ecto; 5' nucleotidase, ecto; 5'-NT; 5'-nucleotidase; 5'-nucleotidase ecto; 5'-nucleotidase, ecto (CD73); AI447961; CALJA; CD73; E5NT; ecto-5'-nucleotidase; eN; eNT; NT; Nt5; Nt5e; NTE; Purine 5-Prime-Nucleotidase
Gene Symbols NT5E
Host Species Rat
Purification Method Affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 23959
Target Species Mouse
Content And Storage 4°C, store in dark, DO NOT FREEZE!
Product Type Antibody
Form Liquid
Isotype IgG1
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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