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Invitrogen™ CD81 Monoclonal Antibody (Eat2), FITC
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Catalog No. PIMA517939
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PIMA517939 100 μg
PIMA517940 300 μg
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Catalog No. PIMA517939 Supplier Invitrogen™ Supplier No. MA517939
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Description

Armenian Hamster Monoclonal Antibody

CD81 Monoclonal Antibody for Flow

CD81 (TAPA-1, target of anti-proliferative antibody-1) is a member of the tetraspanin family, is expressed on virtually all nucleated cells, but above all on germinal center B cells. CD81 forms complexes with other tetraspanin proteins, integrins, coreceptors, MHC class I and II molecules, and influences adhesion, morphology, activation, proliferation and differentiation of B, T cells. In muscles, CD81 promotes cell fusion and myotube maintenance. CD81 has been also identified as a receptor for the hepatitis C virus. Like members of the tetraspanin family that include CD9, CD37, CD53, CD63, and CD82, CD81 is a cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. CD81 is a cell surface glycoprotein that is known to complex with integrins. CD81 appears to promote muscle cell fusion and support myotube maintenance. CD81 associates with CD19, CD21, Leu 13, and integrins on cell membrane and acts as a receptor for the envelope protein E2 of chronic hepatitis C virus. Antibodies to CD81 have anti-proliferative effects on different lymphoid cell lines, particularly those derived from large cell lymphomas. CD81 is also localized in the tumor-suppressor gene region and is a candidate gene for malignancies.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CD81
Applications Flow Cytometry
Classification Monoclonal
Clone Eat2
Concentration 0.1 mg/mL
Conjugate FITC
Formulation PBS with 4-5mg/mL BSA and 0.02% sodium azide
Gene CD81
Gene Accession No. P35762, Q62745
Gene Alias 26 kDa cell surface protein TAPA-1; CD 81 antigen; Cd81; CD81 antigen; CD81 antigen (target of antiproliferative antibody 1); CD81 molecule; CVID6; S5.7; Tapa1; Tapa-1; Target of the antiproliferative antibody 1; Tetraspanin28; tetraspanin-28; Tspan28; Tspan-28
Gene Symbols CD81
Host Species Armenian Hamster
Immunogen CD81 + mouse B lymphoma 38C13.
Purification Method Protein G
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 12520, 25621
Target Species Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Store in the dark.
Product Type Antibody
Form Liquid
Isotype IgG
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