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CD86 Rat anti-Mouse, APC, Clone: GL1, BD
Rat Monoclonal Antibody
$116.00 - $333.50
Specifications
| Antigen | CD86 |
|---|---|
| Clone | GL1 |
| Concentration | 0.2mg/mL |
| Applications | Flow Cytometry |
| Classification | Monoclonal |
| Catalog Number | Mfr. No. | Quantity | Price | Quantity & Availability | |||||
|---|---|---|---|---|---|---|---|---|---|
| Catalog Number | Mfr. No. | Quantity | Price | Quantity & Availability | |||||
|
BDB561964
|
BD Biosciences
561964 |
25 μg |
Each for $116.00
|
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BDB558703
|
BD Biosciences
558703 |
0.1 mg |
Each for $333.50
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Description
The GL1 antibody has been reported to react with the B7-2 (CD86) costimulatory molecule expressed on a broad spectrum of leukocytes, including B lymphocytes, T lymphocytes, thioglycollate-induced peritoneal macrophages, dendritic cells and astrocytes. CD86 is expressed at low levels by freshly explanted peripheral B and T cells, and its expression is substantially increased by a variety of T cell- and B cell-specific stimuli with a peak expression after 18-42 hours of culture. In contrast to most naive CD4+ T cells, memory CD4+ T cells express B7-2, both at the mRNA and protein level. CD86, a ligand for CD28 and CD152 (CTLA-4), is one of the accessory molecules that plays an important role in T cell-B cell costimulatory interactions. It has been shown to be involved in immunoglobulin class-switching and triggering of mouse NK cell-mediated cytotoxicity. CD80 (B7-1) is an alternate ligand for CD28 and CD152 (CTLA-4). GL1 antibody reportedly blocks MLR and stimulation of T cells by natural antigen-presenting cells. In addition, a mixture of anti-B7-1 and anti B7-2 (GL1) mAbs reportedly inhibits the in vitro interaction of CTLA-4 with its ligand and the in vivo priming of cytotoxic T lymphocytes.
Specifications
| CD86 | |
| 0.2mg/mL | |
| Monoclonal | |
| Rat | |
| Mouse | |
| Mouse (CBA/Ca) LPS-activated splenic B Cells | |
| Primary | |
| Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze. |
| GL1 | |
| Flow Cytometry | |
| APC | |
| RUO | |
| Aqueous buffered solution containing ≤0.09% sodium azide. | |
| IgG2a κ | |
| Affinity Purified | |
| B7-2; Ly-58; Cd28l2; Early T-cell costimulatory molecule 1; ETC1; MB7; CLS1 |
For Research Use Only.
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