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Invitrogen™ CD88 (C5aR1) Monoclonal Antibody (S5/1), PerCP-eFluor™ 710, eBioscience™, Invitrogen™
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Catalog No. p-7218906
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100 Tests
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Catalog No. Quantity
46-088-842 100 Tests
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Catalog No. 46-088-842 Supplier Invitrogen™ Supplier No. 46088842
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Description

Mouse Monoclonal Antibody

This S5/1 MAb recognizes human CD88 also known as C5aR1. C5aR1 is a complement receptor widely expressed on cells of the myeloid lineage. Clone S5/1 has been reported to block C5a binding.

CD88, also known as C5aR1, is a C5a Anaphylatoxin Receptor that mediates the effects of one of the most potent chemotactic agents known. C5AR1 has been implicated in asthma, and its expression has been reported in myeloid blood cells, brain, liver, lung, spleen, heart, kidney, and intestinal tract. CD88 is the receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. Functionally, CD88 stimulates chemotaxis, granule enzyme release and superoxide anion production. CD88 is also a component of the classical pathway of the complement cascade; it may be involved with tissue injury associated with ischemia or sepsis and it may be a component of the membrane attack complex. Diseases associated with CD88 include Mannose-Binding Lectin Deficiency and Systemic Lupus Erythematosus.
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Specifications

Antigen CD88 (C5aR1)
Applications Flow Cytometry
Classification Monoclonal
Clone S5/1
Concentration 5 μL/Test
Conjugate PerCP-eFluor 710
Formulation PBS with BSA and 0.09% sodium azide; pH 7.2
Gene C5AR1
Gene Accession No. P21730
Gene Alias anaphylatoxin C5a receptor; C5A; C5a anaphylatoxin chemotactic receptor; C5a anaphylatoxin chemotactic receptor 1; C5a anaphylatoxin receptor; C5a ligand; C5a Receptor; C5AR; C5a-R; C5AR1; C5r1; Cd88; CD88 antigen; complement C5a receptor; complement C5a receptor 1; complement component 5 receptor 1; complement component 5, receptor 1; complement component 5a receptor 1; D7Msu1
Gene Symbols C5AR1
Host Species Mouse
Immunogen BSA-Conjugated Peptide aa. 1-31.
Purification Method Affinity chromatography
Quantity 100 Tests
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 728
Target Species Human
Content And Storage 4°C, store in dark, DO NOT FREEZE!
Product Type Antibody
Form Liquid
Isotype IgG2a κ
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