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CD8a Monoclonal Antibody (YCATE55.9), PerCP-eFluor™ 710, eBioscience™, Invitrogen™
Rat Monoclonal Antibody
$390.00
Specifications
| Antigen | CD8a |
|---|---|
| Clone | YCATE55.9 |
| Applications | Flow Cytometry |
| Classification | Monoclonal |
| Conjugate | PerCP-eFluor 710 |
| Catalog Number | Mfr. No. | Quantity | Price | Quantity & Availability | |||||
|---|---|---|---|---|---|---|---|---|---|
| Catalog Number | Mfr. No. | Quantity | Price | Quantity & Availability | |||||
50-113-0812
|
Invitrogen™
46508042 |
100 Tests |
Each of 1 for $390.00
|
|
|||||
Description
CD8 molecule is composed of two chains termed alpha and beta. CD8 is found on a T cell subset of normal cytotoxic / suppressor cells which make up approximately 20 to 35 % of human peripheral blood lymphocytes. The CD8 antigen is also detected on natural killer cells, 80% of thymocytes, on a subpopulation of 30% of peripheral blood null cells and 15 to 30% of bone marrow cells.
Cluster of differentiation 8 (CD8), a type I transmembrane glycoprotein of the immunoglobulin family of receptors, plays an integral role in signal transduction, and T cell differentiation and activation. CD8 is predominantly expressed on T cells as a disulfide-linked heterodimer of CD8alpha and CD8beta, where it functions as a co-receptor, along with T cell receptor (TCR), for major histocompatibilty complex class I (MHC-I) molecules; whereas its counterpart, CD4, acts as a co-receptor for MHC-II molecules. CD8 exists on the cell surface, where the CD8alpha chain is essential for binding to MHC-I. CD8 is also expressed on a subset of T cells, NK cells, monocytes and dendritic cells as disulfide-linked homodimers of CD8alpha. Ligation of MHC-I/peptide complexes presented by antigen-presenting cells (APCs), triggers the recruitment of lymphocyte-specific protein tyrosine kinase (Lck), which leads to lymphokine production, motility and cytotoxic T lymphocyte (CTL) activation. Once activated, CTLs play a crucial role in the clearance of pathogens and tumor cells. Differentiation of naive CD8+ T cells into CTLs is strongly enhanced by IL-2, IL-12 and TGF-beta1.Specifications
| CD8a | |
| Flow Cytometry | |
| PerCP-eFluor 710 | |
| Rat | |
| Canine | |
| IgG1 κ | |
| Affinity Chromatography |
| YCATE55.9 | |
| Monoclonal | |
| Liquid | |
| RUO | |
| P33706 | |
| Primary | |
| Antibody |
For Research Use Only.
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