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Invitrogen™ CD8b Monoclonal Antibody (SIDI8BEE), PerCP-eFluor™ 710, eBioscience™, Invitrogen™
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Catalog No. 46527342
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46-527-342 100 Tests
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Catalog No. 46-527-342 Supplier Invitrogen™ Supplier No. 46527342
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Description

Mouse Monoclonal Antibody

The SIDI8BEE monoclonal antibody reacts with human and rhesus macaque CD8 beta. The CD8b chain associates with the CD8a chain to form the CD8ab heterodimer expressed on the surface of a majority of thymocytes, and on peripheral cytotoxic alpha beta TCR T

The CD8B antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen, acting as a coreceptor, and the T-cell receptor on the T lymphocyte recognize antigens displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. The functional coreceptor is either a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 beta chain isoforms. Multiple alternatively spliced transcript variants encoding distinct membrane associated or secreted isoforms have been described. A pseudogene, also located on chromosome 2, has been identified.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CD8b
Applications Flow Cytometry
Classification Monoclonal
Clone SIDI8BEE
Concentration 5 μL/Test
Conjugate PerCP-eFluor 710
Formulation PBS with BSA and 0.09% sodium azide; pH 7.2
Gene Cd8b
Gene Accession No. P10966
Gene Alias CD8; CD8 antigen 37 kDa chain; CD8 antigen beta polypeptide; CD8 antigen beta polypeptide precursor; CD8 antigen beta-chain; CD8 antigen, beta chain; CD8 antigen, beta chain 1; CD8 antigen, beta polypeptide 1 (p37); CD8 antigen, beta-chain; CD8 beta; CD8 beta chain; CD8a; CD8alpha; CD8B; CD8b antigen; CD8b molecule; CD8b molecule pseudogene; CD8B1; CD8beta; CD8BP; LEU2; Leu-2; LY3; Ly-3; Ly-C; Lymphocyte antigen 3; Lyt3; Lyt-3; MAL; OX-8 membrane antigen; p32; P37; T lymphocyte surface glycoprotein beta chain; T-cell membrane glycoprotein Ly-3; T-cell surface glycoprotein; T-cell surface glycoprotein CD8 beta chain; T-cell surface glycoprotein Lyt-3
Gene Symbols Cd8b
Host Species Mouse
Purification Method Affinity chromatography
Quantity 100 Tests
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 926
Target Species Human, Monkey
Content And Storage 4°C, store in dark, DO NOT FREEZE!
Product Type Antibody
Form Liquid
Isotype IgG1 κ
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Safety and Handling

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