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Invitrogen™ CD9 Monoclonal Antibody (MEM-61)
Mouse Monoclonal Antibody
Supplier: Invitrogen™ MA119002
Description
This antibody recognizes an epitope on second extracellular domain (EC2) of CD9 antigen, a 24 kDa transmembrane protein expressed on platelets, monocytes, pre-B lymphocytes, granulocytes and activated T lymphocytes. It has also been successfully used in Mass Cytometry (CyTof). Western Blot: non-reducing conditions; Functional Application: Induction.
CD9 antigen is a glycoprotein expressed on the surface of developing B lymphocytes, platelets, monocytes, eosinophils, basophil, stimulated T lymphocytes and by neurons and glial cells in the peripheral nervous system. CD9 belongs to a family of membrane proteins termed tetraspanins which transverse the membrane four times. In pre B cells and platelets, CD9 antigen regulates cell activation and aggregation possibly through an association with the integrin CD41 / CD61 (GPIIb / GPIIIa). CD9 is involved in cell motility, osteoclastogenesis, neurite outgrowth, myotube formation, and sperm-egg fusion, plays roles in cell attachment and proliferation and is necessary for association of heterologous MHC II molecules on the dendritic cell plasma membrane which is important for effective T cell stimulation. CD9 functions in many cellular processes including differentiation, adhesion, and signal transduction, and expression plays a critical role in the suppression of cancer cell motility and metastasis. CD9 is also considered as metastasis suppressor in solid tumors.
Specifications
CD9 | |
Monoclonal | |
1 mg/mL | |
PBS with no preservative; pH 7.4 | |
P21926 | |
CD9 | |
Pre-B cell line NALM-6. | |
100 μg | |
Primary | |
Human | |
Antibody | |
IgG1 |
Flow Cytometry, Functional Assay, Immunohistochemistry (Paraffin), Western Blot | |
MEM-61 | |
Unconjugated | |
CD9 | |
5H9; 5H9 antigen; antigen CD9; BA2; BA-2/p24 antigen; BTCC-1; CD9; CD9 antigen; CD9 antigen (p24); CD9 molecule; cell growth-inhibiting gene 2 protein; DRAP-27; GIG2; Leukocyte antigen MIC3; MIC3; motility related protein-1; Motility-related protein; MRP-1; p24; sCD 9; sCD9; soluble CD 9; soluble CD9; Tetraspanin29; Tetraspanin-29; transmembrane protein CD9; TSPAN29; Tspan-29 | |
Mouse | |
Protein A | |
RUO | |
928 | |
4°C, do not freeze | |
Liquid |
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