ProSci CD99 Recombinant Protein

Catalog No.	Quantity
16-594-231	0.05 mg

Catalog No. 16-594-231 Supplier ProSci Supplier No. 914030050

Description

Recombinant Protein

This recombinant protein can be used for biological assays. For research use only.

CD99 is a type I transmembrane glycoprotein and the founding member of the CD99 family of molecules. The extracellular domain of CD99 contains no identifiable motifs, its cytoplasmic region, although short, does have signal transduction capability. Cells known to express CD99 include fibroblasts, neutrophils, T cells, double positive thymocytes, CD34+ stem cells, monocytes and endothelial cells. Two types of CD99 isoforms have been classified. Native human CD99 is referred to as the long, or type I isoform. The best studied type II isoform shows an Asp-Gly substitution for the C terminal 27 amino acids. The type I and II isoforms have distinctive signal transduction pathways (FAKsrc for type I PI3K plus srcERK1/2 for type II), and mediate clearly different biological outcomes. Homophilic interaction between CD99 on the neutrophil and CD99 on the endothelial cell regulates the transendothelial migration of neutrophils during inflammation. Human CD99 has 48% aa sequence identity to mouse CD99.

Specifications

• Accession Number: P14209
• Gene ID (Entrez): 4267
• Molecular Weight (g/mol): 11.13 kDa
• Quantity: 0.05 mg
• Source: Human Cells
• Common Name: CD99 molecule
• Gene Symbol: CD99
• Conjugate: Unconjugated
• Species: Human
• Recombinant: Recombinant
• Protein Tag: C-6 His tag
• Sequence: Asp23-Asp122
• Content And Storage: Lyophilized protein should be stored at -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4°C to 7°C for 2-7 days. Aliquots of reconstituted samples are stable (at -20°C for 3 months.)
• Purity or Quality Grade: >95% as determined by reducing SDS-PAGE. Endotoxin level less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test.
• Synonym: CD99 Antigen, 12E7, E2 Antigen, Protein MIC2, T-Cell Surface Glycoprotein E2, CD99, MIC2, MIC2X, MIC2Y