Invitrogen™ Cdc37 Recombinant Rabbit Monoclonal Antibody (10C3)

Rabbit Recombinant Monoclonal Antibody

Supplier:  Invitrogen™ MA538413

Catalog No. PIMA538413

Description

This antibody has been tested in direct-ELISA.

In S. cerevisiae, Cdc37 has been shown to be an important regulator of cell division cycle through its action on cyclin-dependent kinases (CDK's). Cdc37 has also been associated with signaling pathways and kinases unrelated to cell cycle control, including v-Src, casein kinase II, MPS1 kinase and the sevenless receptor tyrosine kinase. Interestingly, HSP90 has also been shown to be associated with many of the same cellular targets as Cdc37. It has now been shown that Cdc37 is the same protein previously described as p50 which has been found to be associated with many of the same proteins as HSP90. Among others, Cdc37/p50 has been found complexed with Src-family kinases (Fyn, Yes, Fes, Lck & Fgr), Raf and pp60v-src. More recently, Cdc37 has been shown to be a chaperone independently and in concert with HSP90. In fact, Cdc37 is necessary for the binding of HSP90 to Cdk4.

Specifications

• Antigen: Cdc37
• Classification: Recombinant Monoclonal
• Concentration: 0.12 mg/mL
• Formulation: PBS with 50% glycerol, 150mM NaCl and 0.02% sodium azide; pH 7.4
• Gene Accession No.: Q16543
• Gene Symbols: CDC37
• Immunogen: A synthesized peptide derived from human Cdc37 (aa 9-24).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

• Applications: Flow Cytometry, Western Blot
• Clone: 10C3
• Conjugate: Unconjugated
• Gene: CDC37
• Gene Alias: CDC 37; CDC37; CDC37 (cell division cycle 37 S. cerevisiae homolog); CDC37 (cell division cycle 37, S. cerevisiae, homolog); CDC37 cell division cycle 37 homolog; Cdc37 homolog; CDC37 protein; CDC37A; Cdc37p; Cell division control protein 37; cell division cycle 37; cell division cycle 37 homolog; hsp90 chaperone protein kinase-targeting subunit; Hsp90 co-chaperone Cdc37; Hsp90 co-chaperone Cdc37, N-terminally processed; p50; P50CDC37; SMO1; YD9489.03; YDR168W
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 11140
• Content And Storage: -20°C or -80°C if preferred
• Form: Liquid