CDC37 Mouse anti-Human, Mouse, Rat, Clone: 1C2A6, Proteintech

Mouse Monoclonal Antibody

Supplier:  Proteintech Group Inc 664201IG150UL

Catalog No. 50-173-6847

Description

In S. cerevisiae, Cdc37 has been shown to be an important regulator of cell division cycle through its action on cyclin-dependent kinases (CDK′s). Cdc37 has also been associated with signaling pathways and kinases unrelated to cell cycle control, including v-Src, casein kinase II, MPS1 kinase and the sevenless receptor tyrosine kinase. Interestingly, HSP90 has also been shown to be associated with many of the same cellular targets as Cdc37. It has now been shown that Cdc37 is the same protein previously described as p50 which has been found to be associated with many of the same proteins as HSP90. Among others, Cdc37/p50 has been found complexed with Src-family kinases (Fyn, Yes, Fes, Lck & Fgr), Raf and pp60v-src. More recently, Cdc37 has been shown to be a chaperone independently and in concert with HSP90. In fact, Cdc37 is necessary for the binding of HSP90 to Cdk4.

Specifications

• Antigen: CDC37
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: Q16543, Q61081, Q63692
• Gene Symbols: Cdc37
• Immunogen: CDC37 Fusion Protein Ag0267
• Quantity: 150 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG2a

• Applications: Immunocytochemistry, Immunofluorescence, Western Blot
• Clone: 1C2A6
• Conjugate: Unconjugated
• Gene: CDC37
• Gene Alias: CDC37, CDC37A, Hsp90 co chaperone Cdc37, P50CDC37
• Host Species: Mouse
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 11140, 114562, 12539
• Content And Storage: -20°C
• Form: Liquid