CDC42BPA Monoclonal Antibody (OTI7B9), TrueMAB™, OriGene

Catalog No.	Quantity
50-168-1979	100 μL

Catalog No. 50-168-1979 Supplier OriGene Supplier No. TA808223

Description

Mouse Monoclonal Antibody

MRCK alpha (myotonic dystrophy kinase-related Cdc42-binding kinase alpha) is a member of the dystrophia myotonica protein kinase (DMPK) family that functions downstream of Cdc42 in actin cytoskeletal reorganization. It is a serine/threonine kinase with multiple functional domains, including phorbol ester-responsive C1 domain. Three independent coiled-coil domains and the N-terminal region preceding the kinase domain are responsible for intermolecular interactions leading to MRCK alpha multimerization. The transautophosphorylation process is critical for regulation of MRCK alpha catalytic activities. Binding of phorbol esters to MRCK releases its autoinhibition, allowing N-terminal dimerization and subsequent kinase activation.

Specifications

• Antigen: CDC42BPA
• Applications: Western Blot
• Classification: Monoclonal
• Clone: OTI7B9
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
• Gene: CDC42BPA
• Gene Accession No.: Q5VT25
• Gene Alias: MRCK, MRCKA, PK428
• Gene Symbols: CDC42BPA
• Host Species: Mouse
• Immunogen: Human recombit protein fragment corresponding to amino acids 1419-1638 of human CDC42BPA produced in E.coli.
• Purification Method: Affinity Chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 8476
• Target Species: Human
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG1