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Invitrogen™ CDCA8 Polyclonal Antibody
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Catalog No. PIPA555978
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PIPA555978 100 μL
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Catalog No. PIPA555978 Supplier Invitrogen™ Supplier No. PA555978
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: LRTPAAGERI YNISGNGSPL ADSKEIFLTV PVGGGESLRL LASDLQRHSI AQLDPEALGN IKKLSNRLAQ ICSSIRTHK Highest antigen sequence identity to the following orthologs: Mouse - 81%, Rat - 82%.

CDCA8 is a component of a chromosomal passenger complex (CPC) required for stability of the bipolar mitotic spindle. The chromosomal passenger complex, which includes Survivin, CDCA8, INCENP and Aurora-B, is known to play crucial roles during mitosis and cell division. It was found that CDCA8 interacting with Aurora-B, INCENP and Survivin, increases during G2/M phase and then reduces after exit from M phase. CDCA8 is cell cycle regulated, down-regulated in response to p53/Rb-signaling, and up-regulated in many types of cancerous tissues. In Drosophila cells, inactivation of CDCA8 results in polyploidy, delayed mitosis and abnormal tissue development, indicating its critical role for cell proliferation. Recent studies show that CDCA8 is essential for cell proliferation during early embryonic development, and its early embryonic lethality cannot be rescued by the loss of p53. Its aberrant expression is linked to a poor prognosis for gastric cancer.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CDCA8
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 0.1 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene CDCA8
Gene Accession No. Q53HL2
Gene Alias 4831429J16Rik; AU044747; BOR; Borealin; Cdca8; cell division cycle associated 8; cell division cycle-associated protein 8; D4Ertd421e; Dasra B; DasraB; dasra-B; embryonic stem cell-related; hDasra-B; MESrg; MESRGP; PESCRG3; Pluripotent embryonic stem cell-related gene 3 protein
Gene Symbols CDCA8
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human CDCA8. Recombinant protein control fragment (Product #RP-94216).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 55143
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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