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Invitrogen™ CDK4 Monoclonal Antibody (DCS-31.2)
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Catalog No. PIMA182085
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100 μg
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Catalog No. Quantity
PIMA182085 100 μg
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Catalog No. PIMA182085 Supplier Invitrogen™ Supplier No. MA182085
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Description

Mouse Monoclonal Antibody

Mouse anti CDK4 antibody clone DCS31.2 recognizes cyclin dependent kinase 4 (Cdk4), a ~34 kDa protein involved in the regulation of cell cycle progression between G1 and S.Mouse anti CDK4 antibody clone DCS31.2 does not cross react with other cdk's and does not co-precipitate the D type cyclins bound to cdk4.

CDK4/cyclin D3 serine/threonine kinase is dimeric protein complex. CDK4 is a member of the cyclin-dependent protein kinase family and is involved in the control of cell proliferation during the G1 phase of cell cycle. CDK4 forms a complex with the D-type cyclins and is inhibited by p16 (cyclin-dependent kinase inhibitor-2). CDK4 can mediate phosphorylation of the C-terminal region of Rb protein leading to an active transcriptional repression of E2F complex. CDC37 and HSP90 can preferentially associate with the fraction of CDK4 not bound to D-type cyclins. SMAD3 is a major physiologic substrate of the G1 cyclin-dependent kinases CDK4 and CDK2. Although CDK6 and CDK4 can both phosphorylate multiple residues in the Rb protein, they do so with different residue selectivity in vitro; CDK6 phosphorylates Thr821 while CDK4 phosphorylates Thr826 on Rb protein.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CDK4
Applications Immunohistochemistry (Frozen), Immunoprecipitation, Western Blot
Classification Monoclonal
Clone DCS-31.2
Concentration 1.0 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.08% sodium azide
Gene Cdk4
Gene Accession No. P11802, P30285, P35426
Gene Alias Cdk4; Cell division protein kinase 4; CMM3; Crk3; cyclin dependent kinase 4; cyclin-dependent kinase 4; MGC14458; p34>PSK-J3>/cdk4; PSK-J3; serine/threonine kinase; Unknown (protein for MGC:133903)
Gene Symbols Cdk4
Host Species Mouse
Immunogen Proprietary Immunogen.
Purification Method Purified
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 1019, 12567, 94201
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG1
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