Learn More
Invitrogen™ CDK4 Monoclonal Antibody (DCS-31)
Mouse Monoclonal Antibody
Supplier: Invitrogen™ AHZ0202

Description
This antibody reacts with an epitope at aa 16-35. Recommended positive controls include MAD109, LS174T, and PC12 cells.
CDK4/cyclin D3 serine/threonine kinase is dimeric protein complex. CDK4 is a member of the cyclin-dependent protein kinase family and is involved in the control of cell proliferation during the G1 phase of cell cycle. CDK4 forms a complex with the D-type cyclins and is inhibited by p16 (cyclin-dependent kinase inhibitor-2). CDK4 can mediate phosphorylation of the C-terminal region of Rb protein leading to an active transcriptional repression of E2F complex. CDC37 and HSP90 can preferentially associate with the fraction of CDK4 not bound to D-type cyclins. SMAD3 is a major physiologic substrate of the G1 cyclin-dependent kinases CDK4 and CDK2. Although CDK6 and CDK4 can both phosphorylate multiple residues in the Rb protein, they do so with different residue selectivity in vitro; CDK6 phosphorylates Thr821 while CDK4 phosphorylates Thr826 on Rb protein.
Specifications
CDK4 | |
Monoclonal | |
0.4 mg/mL | |
PBS with 0.2% BSA and 0.09% sodium azide; pH 7.4 | |
P11802, P30285, P35426 | |
Cdk4 | |
Purified recombinant cdk4 protein. | |
500 μL | |
Primary | |
Human, Mouse, Rat | |
Antibody | |
IgG1 |
Flow Cytometry, Immunoprecipitation, Western Blot, Western Blot | |
DCS-31 | |
Unconjugated | |
Cdk4 | |
Cdk4; Cell division protein kinase 4; CMM3; Crk3; cyclin dependent kinase 4; cyclin-dependent kinase 4; MGC14458; p34>PSK-J3>/cdk4; PSK-J3; serine/threonine kinase; Unknown (protein for MGC:133903) | |
Mouse | |
Protein G | |
RUO | |
1019, 12567, 94201 | |
4°C | |
Liquid | |
Responsibly packaged |
The Fisher Scientific Encompass Program offers items which are not part of our distribution portfolio. These products typically do not have pictures or detailed descriptions. However, we are committed to improving your shopping experience. Please use the form below to provide feedback related to the content on this product.