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Invitrogen™ CDK8 Polyclonal Antibody
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Catalog No. PIPA595617
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100 μg
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PIPA595617 100 μg
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Catalog No. PIPA595617 Supplier Invitrogen™ Supplier No. PA595617
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Description

Rabbit Polyclonal Antibody

Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 μg/mL. Positive Control - WB: human Hela whole cell, human K562 whole cell, human Jurkat whole cell, human Caco-2 whole cell, human HEK293 whole cell. Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

CDK8 phosphorylates the carboxy-terminal domain of the largest subunit of RNA polymerase II. This protein is coexpressed and copurified with Cyclin C. CDK8 is part of a family of proteins designated as cdks are critical regulators of cell cycle progression. The prototype member of this family, p34/Cdc 2, and a related protein Cdk 2, function late in the cycle while Cdk 4 and Cdk 6 are critically involved in G1 to S progression. Because of analogy with yeast Cdk 8, it has been proposed that the human Cdk 8 Cyclin C may interact with RNA polymerase, thus influencing the transcription mechanism(s) that lead to cell division.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CDK8
Applications ELISA, Western Blot
Classification Polyclonal
Concentration 500 μg/mL
Conjugate Unconjugated
Formulation PBS with 4mg trehalose and 0.05mg sodium azide
Gene Cdk8
Gene Accession No. P49336
Gene Alias Cdk8; CDK8 protein kinase; cell division protein kinase 8; Cell division protein kinase 8-like protein; cyclin dependent kinase 8; cyclin-dependent kinase 8; K35; mediator complex subunit CDK8; Mediator of RNA polymerase II transcription subunit CDK8; MGC126074; MGC126075; protein kinase K35; RGD1560888; wu:fk95h11
Gene Symbols Cdk8
Host Species Rabbit
Immunogen E.coli-derived human Cdk8 recombinant protein (K355-Y464).
Purification Method Affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 1024
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Lyophilized
Isotype IgG
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