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Invitrogen™ CDK9 Monoclonal Antibody (K.513.1)
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Catalog No. PIMA514912
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100 μL
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PIMA514912 100 μL
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Catalog No. PIMA514912 Supplier Invitrogen™ Supplier No. MA514912
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Description

Rabbit Monoclonal Antibody

It is not recommended to aliquot this antibody.

CDK9 is a serine/threonine kinase which when complexed with CyclinT1 forms an active holoenzyme complex. This complex plays a key role in regulating the eukaryotic cell cycle. CDK9 is coexpressed and copurified with CyclinT1. CDK9 regulates cytokine inducible transcription networks by facilitating promoter recognition of target transcription factors. CDK9 promotes RNA synthesis in genetic programs for cell growth, differentiation, and viral pathogenesis. The CDK9/cyclin-K complex also has kinase activity towards CTD of RNAPII and can substitute for CDK9/cyclin-T P-TEFb in vitro. Chronic activation of CDK9 causes cardiac myocyte enlargement leading to cardiac hypertrophy and confers a predisposition to heart failure.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CDK9
Applications Flow Cytometry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot, Immunocytochemistry
Classification Monoclonal
Clone K.513.1
Concentration 163 μg/mL
Conjugate Unconjugated
Formulation 0.01M HEPES with 100μg/mL BSA, 50% glycerol, 0.15M NaCl and <0.02% sodium azide; pH 7.5
Gene CDK9
Gene Accession No. P50750, Q5EAB2, Q641Z4, Q99J95
Gene Alias C-2k; CDC2L4; CDC2-related kinase; Cdk9; Cell division cycle 2-like protein kinase 4; Cell division protein kinase 9; CTK1; cyclin dependent kinase 9; cyclin-dependent kinase 9; cyclin-dependent kinase 9 (CDC2-related kinase); PITALRE; RP11-228B15.5; serine/threonine protein kinase PITALRE; Serine/threonine-protein kinase PITALRE; TAK; Tat-associated kinase complex catalytic subunit
Gene Symbols CDK9
Host Species Rabbit
Immunogen Synthetic peptide corresponding to residues near the carboxy terminus of human CDK9.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 100757719, 100855805, 1025, 107951, 362110, 520580
Target Species Human, Mouse, Rat, Canine, Monkey, Bovine, Hamster
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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