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Invitrogen™ CDNF Monoclonal Antibody (D2), Invitrogen™

Catalog No. p-7240999
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100 μL
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PIMA543893 20 μL
PIMA543892 100 μL
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Catalog No. PIMA543893 Supplier Invitrogen™ Supplier No. MA543893
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Description

Mouse Monoclonal Antibody

The conserved dopamine neurotrophic factor (CDNF) is a neurotrophic factor for dopaminergic neurons and highly homologous to the mesencephalic-astrocyte-derived neuro-trophic factor. Somewhat surprisingly, CDCF is expressed at higher levels in tissues such as heart, skeletal muscle and testes than in brain. Similar to the glial cell line-derived neurotrophic factor (GDNF), CDNF can prevent the 6-hydroxylamine (6 OHDA) induced degeneration of dopaminergic neurons in a rat model of Parkinsons disease. Furthermore, CDNF was able to restore the dopaminergic function and prevent the degeneration of dopaminergic neurons in the substantia nigra, suggesting that CDNF might be suitable for the treatment of Parkinsons disease. At least two isoforms of CDNF are known to exist.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CDNF
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Monoclonal
Clone D2
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.05% ProClin 300; pH 7.4
Gene Cdnf
Gene Accession No. Q49AH0
Gene Alias 9330140G23; arginine-rich protein mutated in early stage tumors-like 1; arginine-rich, mutated in early stage tumors-like 1; ARMETL1; ARMET-like protein 1; Cdnf; Cerebral dopamine neurotrophic factor; conserved dopamine neurotrophic factor
Gene Symbols Cdnf
Host Species Mouse
Immunogen Pro33-Leu187 (Accession Q49AH0), with N-terminal His and GST Tag.
Purification Method Protein A/G
Quantity 20 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 441549
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG2b κ
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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