Cefotaxime Sodium Salt, MP Biomedicals™

Description

Inhibits bacterial cell wall synthesis. Cefotaxime Sodium Salt, MP Biomedicals is a cephalosporin antibiotic that is active against both gram-negative and gram-positive bacteria. It is used for infections of the respiratory tract, skin, bones, joints, uro

Cefotaxime binds to penicillin-binding proteins (PBPs), which inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell walls. As a result, bacteria lyse due to cell wall autolytic enzymes. Cefotaxime blocks the division of cyanobacteria and lower plant organelles/plastids such as the photosynthetic organelles of Glaucophytes and chloroplasts of bryophytes. Cefotaxime is used to treat a variety of bacterial infections:

• Good coverage against most Gram-negative bacteria, with the notable exception of Pseudomonas
• Effective against most Gram-positive cocci, except for Enterococcus
• Active against penicillin-resistant strains of Streptococcus pneumoniae
• Modest activity against the anaerobic Bacteroides fragilis
• In meningitis, cefotaxime crosses the blood–brain barrier better than cefuroxime

Specifications

Chemical Identifiers

• CAS: 64485-93-4
• Molecular Formula: C16H16N5NaO7S2
• Molecular Weight (g/mol): 477.44
• MDL Number: MFCD00079073
• InChI Key: AZZMGZXNTDTSME-JUZDKLSSSA-M
• Synonym: Cefotaxime sodium, (6R-(6-a,7-b(Z)))-3-((Acetyloxy) methyl)-7- (((2-amino-4-thiazolyl) (methoxyimio) acetyl) amino)-8- oxo-5-thia-1- azabicyclo (4,2,0) oct-2-ene-2-carboxylic acid, sodium salt
• PubChem CID: 88631411
• IUPAC Name: sodium;(6S,7R)-3-(acetyloxymethyl)-7-[[2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
• SMILES: [Na+].CO\N=C(/C(=O)N[C@H]1[C@H]2SCC(COC(C)=O)=C(N2C1=O)C([O-])=O)C1=CSC(N)=N1

• Physical Form: Powder
• Quantity: 1 g
• Solubility Information: Soluble in water (0.05gm/1mL, clear, light yellow solution).
• Formula Weight: 477.45
• Percent Purity: ≥95%

Safety and Handling

Recommended Storage

Store at 4°C, protect from light.

WARNING: Reproductive Harm - www.P65Warnings.ca.gov