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Enzo Life Sciences Celastrol (25mg). CAS: 34157-83-0
SDP

Supplier:  Enzo Life Sciences ALX350332M025

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Cell permeable triterpenoid; anti-inflammatory and immunosuppressive compound. Antioxidant. Suppresses LPS-induced cytokine release in macrophages and monocytes (IC50=40nM for IL-1β and IL-1α, 80nM for IL-6, 110nM for prostaglandin E2 and 210nM for IL-8 and TNF-α). Suppresses nitric oxide (NO) production (IC50=230nM) and LPS-induced NF-κB activation (IC50=270nM). Inhibits chymotrypsin-like activity of 20S proteasome (IC50=2.5µM). Inhibits lipid peroxidation induced by ADP and Fe2+ in rat liver mitochondria (IC50=7µM). Induces expression of a wider set of heat shock proteins. Inhibits topoisomerase II. Alternative name: Tripterine, 3-Hydroxy-24-nor-2-oxo-1(10),3,5,7-friedelatetraen-29-oic acid. Purity: ≥98% (HPLC). Solubility: Soluble in 100% ethanol, DMSO or dimethyl formamide; insoluble in water. Long Term Storage: -20°C.

Catalog No. 50-200-8846


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