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Description
Recommended positive controls: , BE cells. This antibody does not cross react with mouse CENPA proteins. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Centromeres are the differentiated chromosomal domains that specify the mitotic behavior of chromosomes. CENPA encodes a centromere protein which contains a histone H3 related histone fold domain that is required for targeting to the centromere. CENPA is proposed to be a component of a modified nucleosome or nucleosome-like structure in which it replaces 1 or both copies of conventional histone H3 in the (H3-H4)2 tetrameric core of the nucleosome particle.
Specifications
Specifications
| Antigen | CENPA |
| Applications | ChIP Assay, Immunohistochemistry (Paraffin), Neutralization, Western Blot, Immunocytochemistry |
| Classification | Monoclonal |
| Clone | 3-19 |
| Concentration | 1 mg/mL |
| Conjugate | Unconjugated |
| Formulation | PBS with 50% glycerol and no preservative; pH 7.2 |
| Gene | Cenpa |
| Gene Accession No. | P49450, Q6XXM1 |
| Gene Alias | CenH3; CENP A; CENPA; CENP-A; Centromere autoantigen A; centromere protein A; centromere protein A, 17kDa; centromere-specific histone; ggCENP-A; histone H3-like centromeric protein A; RGD1563607 |
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Safety and Handling
WARNING: Cancer - www.P65Warnings.ca.gov
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