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Invitrogen™ CENPB Monoclonal Antibody (A5F6)
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Catalog No. PIMA542559
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100 μL
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PIMA542559 100 μL
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Catalog No. PIMA542559 Supplier Invitrogen™ Supplier No. MA542559
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Description

Mouse Monoclonal Antibody

Positive Control: Hela cell lysate, A549 cell lysate, MCF-7 cell lysate, SH-SY5Y, human kidney tissue, human skin tissue. Subcellular Location: Nucleus, centromere.

CENPB is a highly conserved protein that facilitates centromere formation. It is a DNA-binding protein that is derived from transposases of the pogo DNA transposon family. It contains a helix-loop-helix DNA binding motif at the N-terminus, and a dimerization domain at the C-terminus. It is also considered a major centromere autoantigen recognized by sera from patients with anti-centromere antibodies. This gene product is a highly conserved protein that facilitates centromere formation. It is a DNA-binding protein that is derived from transposases of the pogo DNA transposon family. It contains a helix-loop-helix DNA binding motif at the N-terminus, and a dimerization domain at the C-terminus. The DNA binding domain recognizes and binds a 17-bp sequence (CENP-B box) in the centromeric alpha satellite DNA. This protein is proposed to play an important role in the assembly of specific centromere structures in interphase nuclei and on mitotic chromosomes and is considered a major centromere autoantigen recognized by sera from patients with anti-centromere antibodies.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CENPB
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Monoclonal
Clone A5F6
Concentration 2 mg/mL
Conjugate Unconjugated
Formulation TBS with 0.2% BSA, 50% glycerol and 0.05% sodium azide; pH 7.4
Gene CENPB
Gene Accession No. P07199
Gene Alias CENPB; CENP-B; CENP-B protein; centromere autoantigen B; centromere protein B; centromere protein B, 80kDa; major centromere autoantigen B
Gene Symbols CENPB
Host Species Mouse
Immunogen Recombinant protein within human CENPB aa 1-200.
Purification Method Protein G
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 1059
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG2a
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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